Compositions and methods for a universal clinical test for olfactory dysfunction

ABSTRACT

Disclosed are compositions and methods for measuring olfactory sensitivity, olfactory resolution, and combinations thereof. Such measurements can be made during a single test, or over consecutive tests, which may be performed during a single testing period, such as in a single day, or over a series of testing periods. The tests may be performed by a health care professional, or may be conveniently self-administered by the user.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.16/628,075, filed on Jan. 2, 2020, which is a National Phase ofInternational Application No. PCT/US2018/040704, filed on Jul. 3, 2018,which claims priority to U.S. Provisional Application No. 62/528,420,filed on Jul. 3, 2017, the disclosures of each of which are herebyincorporated by reference.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH

This invention was made with government support under grant no. UL1TR000043 awarded by National Institutes of Health. The government hascertain rights in the invention.

FIELD OF THE DISCLOSURE

The disclosure generally relates to compositions and methods of sensorydiagnosis and/or repair.

BACKGROUND OF THE DISCLOSURE

Smell dysfunction manifests itself primarily in the reduced ability todetect or identify volatile chemicals, and ranges from the completeinability to smell any odors, to a partial reduction in olfactorysensitivity, to smell distortion, for instance that a large number ofodors smell like cigarette smoke. The prevalence of smell dysfunction inthe general adult population is about 20% in Europe and the UnitedStates (1-3). This condition is dangerous because those affected areunable to detect fire, spoiled food, hazardous chemicals, and leaks ofodorized natural gas (4, 5). Smell loss also has severe healthconsequences, including mental health symptoms such as depression,anxiety, and social isolation. It affects quality of life by alteringfood preferences and the amount of food ingested (5). Food is oftenperceived as bland or tasteless by patients with smell disorders,leading to loss of appetite or overeating (4, 5).

Smell dysfunction has many causes, including head trauma, upperrespiratory tract infection, nasal polyps, and congenital anomalies (6,7). In many cases, the cause of smell dysfunction is unknown (5, 8).Importantly, smell dysfunction is an early sign of Alzheimer's disease(9), the most common cause of dementia in the United States that isprojected to affect an estimated 1 in every 45 individuals by 2050 (10).There is growing evidence that diminished olfactory function arisesearly in the progression of Alzheimer's disease, and is highlypredictive of future cognitive decline (3, 4). Because of the highprevalence and dramatic consequences of smell loss, accurate diagnosisof olfactory dysfunction is important. While self-reported hearing losstends to be accurate (11), self-reporting of olfactory dysfunction isnotoriously unreliable. Therefore, accurate diagnostic tests for smelldysfunction that can be deployed worldwide are critically important.Following a diagnosis, therapeutic options and counselling can beoffered to patients suffering from smell loss (12).

In clinical smell testing, patients are presented with odor stimuli in avariety of formats, including scratch ‘n’ sniff strips, glass vials orjars, felt-tip pens, or paper scent strips used in perfume shops, andasked to answer questions about what they smell. Smell tests assess theability of subjects to detect, discriminate, or identify odors.Olfactory threshold tests measure the lowest concentration of an odorstimulus that a patient can perceive, while discrimination tests assessthe ability of subjects to distinguish two different smells. Finally,odor identification tests evaluate whether a patient can detect andmatch odors to standard words that describe the smell (13).

There are at least two major challenges to reliably testing a patient'ssense of smell. First, sensitivity to monomolecular odorants variesgreatly even among subjects with a normal sense of smell (14-16). Allcommercial smell tests that use monomolecular odorants therefore run thedanger of misdiagnosing patients. For instance, when a patient has a lowscore on a test that assesses olfactory sensitivity with the rose-likeodor phenyl ethyl alcohol (17), it is difficult to know whether thepatient suffers from general smell dysfunction, or is merely insensitiveto phenylethyl alcohol with an otherwise normal sense of smell.

The second challenge is to develop a test that is not influenced by thepatient's prior olfactory experiences. This has an obvious influence onthe results of odor identification tests such as the University ofPennsylvania Smell Identification Test (UPSIT) for which subjects aregiven a booklet with 40 scratch ‘n’ sniff items and asked to select oneof four words (for example “gingerbread”, “menthol”, “apple”, or“cheddar cheese”) that best describes what the odor smells like. Whethera patient can correctly identify the smell of gingerbread depends notonly on the patient's sense of smell, but also on whether the patienthas previously encountered the smell of gingerbread. This in turndepends on many factors such as the cultural and age group the patientbelongs to. To address this familiarity problem, the UPSIT has beenadapted for use in a number of countries worldwide by replacingunfamiliar items and adapting the answers on the multiple-choice test.For instance, the North American UPSIT was adapted for Taiwanesesubjects by replacing “clove”, “cheddar cheese”, “cinnamon”,“gingerbread”, “dill pickle”, “lime”, “wintergreen”, and “grass” with“sandalwood”, “fish”, “coffee”, “rubber tire”, “jasmine”, “grapefruit”,“magnolia”, and “baby powder” (18). The strong influence of priorolfactory experience on the test results limits the utility of odoridentification tests. Even performance on non-semantic odordiscrimination tasks depends on prior experience with the odorants (19,20), and it is therefore important to avoid stimuli having differentialfamiliarity in the test population. Thus, there is an ongoing and unmetneed to develop new compositions and methods for assessing olfactoryfunction. The present disclosure is pertinent to this need.

SUMMARY OF THE DISCLOSURE

The present disclosure provides compositions, kits, and methods fordetermining olfactory sensitivity and olfactory resolution. Thedisclosure provides distinct ensembles of odorants that can be used inmaking such determinations. In some embodiments, odorants are providedin a plurality of dilutions, such as serial dilutions, such thatiterative exposure to the distinct dilutions provides for quantifyingand/or scoring olfactory sensitivity and/or resolution. In onenon-limiting approach, the lowest concentration of an odor stimulus thata subject can perceive is determined, and used to provide a value forolfactory sensitivity. In another non-limiting approach, a subject'scapacity to distinguish distinct smells from one another is quantifiedand/or scored to provide a value for olfactory resolution. Certainaspects of olfactory resolution and/or sensitivity can be assessed usinga variety of experimental designs, a non-limiting example of whichcomprises a triangle test, whereby the capacity of an individual todetermine the presence or absence of an olfactory stimulus, and/or todiscriminate between distinct olfactory stimuli, is analyzed.

In embodiments, a value determined using an approach described hereincan be used to assist in a diagnosis of an olfactory defect, and/oranother condition or disorder that is correlated with olfactory sensoryacuity, for example, by determining a sensitivity and/or resolutionvalue that is lower or different from a threshold or reference value.

In embodiments, methods of the disclosure can comprise performance oftriangle tests. Triangle tests are known to those skilled in the art asa discriminative approach used in sensory science to determine thepresence or absence of a stimulus, and/or a difference between distinctsamples, such as by asking a subject to select one of three stimuli thatis different from the other two.

Kits comprising combinations of odorants described herein are alsoprovided.

BRIEF DESCRIPTION OF THE FIGURES

For a fuller understanding of the nature and objects of the disclosure,reference should be made to the following detailed description taken inconjunction with the accompanying figures.

FIG. 1 shows SMELL-S olfactory sensitivity and SMELL-R olfactoryresolution tests. (A) Schematic of triangle test stimuli for SMELL-S,comprising two glass vials containing solvent (gray) and one containingincreasingly diluted mixtures of 30 molecules (red-white mosaic).Olfactory sensitivity of a subject measured with SMELL-S [Subject Expt1-A023, SMELL-S (v2)]. (B) Schematic of triangle test stimuli forSMELL-R, comprising two jars containing the same mixture of 30 molecules(red-white mosaic) and a one containing mixtures of 30 molecules(black-gray mosaic) with an increasing number of molecules shared withthe other two. Olfactory resolution of a subject measured with SMELL-R[Subject Expt 1-A016, SMELL-R (v1)]. Circles in A and B indicatestarting level for each test.

FIG. 2 shows test-retest reliability and relationship between SMELL-Sand SMELL-R tests. (A) Experiment 1 design, showing one example of themany different presentations of the six smell tests. SMELL-R tests werealways administered after SMELL-S or threshold tests in a given visit.(B) Bland-Altman plots of the indicated tests where each dot representsdata from one subject. Black dotted lines represent the average ofdifferences between retest and test scores, and gray areas indicate 95%limits of agreement (average difference±1.96 S.D. of the difference,n=74-75). (C) Test and retest scores for SMELL-R (v1) and SMELL-R (v2)where each dot represents data from one subject (ICC=intraclasscorrelation coefficient; n=73-75).

FIG. 3 shows addressing the problem of odor-specific insensitivity. (A)Subject average scores of the indicated tests from Experiment 1 betweentest and retest. Data marked with different letters indicatesignificantly different inter-individual variance between groups(p<0.0001; Conover squared ranks test, n=74-75). Data from the sevenlowest-scoring subjects in the phenylethyl alcohol test are connected bylines. (B) Experiment 2 design. (C) The relationship between differentetiologies of olfactory dysfunction and UPSIT scores in publishedstudies, as well as of Experiment 2 subjects divided by self-reportedsmell abilities (mean±95% confidence interval). References: KorsakoffSyndrome (43), traumatic brain injury (45), sinonasal disease (45),Parkinson's Disease (46), postviral olfactory dysfunction (45), amnesticmild cognitive impairment (9), elderly at higher risk of cognitivedecline (9), non-amnestic mild cognitive impaired (9), and toxicexposure (47). (D) UPSIT scores for subjects divided into normal anddysfunctional groups according to phenylethyl alcohol threshold(Sniffin' Sticks) (cut-off score=6.5) performance, where each dotrepresents data from one subject. Subjects scored as normal by the UPSITbut dysfunctional by Sniffin' Sticks phenylethyl alcohol test arecolored in red in D and E. Data from the remaining subjects are coloredbrown here and in E. Data labeled with different letters aresignificantly different (p=0.0003, Mann-Whitney test). Medians andinterquartile range are represented. (F) Comparison of UPSIT andphenylethyl alcohol (Sniffin' Sticks) scores. (F) UPSIT scores forsubjects divided into normal and dysfunctional groups according SMELL-S(v2) (cut-off score=7) performance, where each dot represents data fromone subject. Subjects scored as normal by the UPSIT but dysfunctional bySniffin' Sticks phenylethyl alcohol test in D are colored red in F andG, while the others are in blue. Data labeled with different letters aresignificantly different (p<0.0001; Mann-Whitney test), and representedas median and interquartile range. (G) Comparison between UPSIT andSMELL-S (v2) scores. Subjects with identical values are indicated bysuperimposed open circles and an X, and retain the specified colorcoding.

FIG. 4 shows SMELL-S and SMELL-R diagnostic accuracy. (A) Comparison ofUPSIT and SMELL-S (v2) scores for Experiment 2 subjects (mean±S.D.)Subjects were divided into dysfunctional (n=7) and normal (n=26) usingan UPSIT cut-off score of 29. Data labeled with different letters aresignificantly different (p=0.0005, two-sided unpaired t-test withWelch's correction). (B) Area under the ROC curve (AUC) for SMELL-S(v2). The optimal cut-off is indicated by the blue dot. (C) Plots offour measures of diagnostic accuracy resulting from different cut-offscores for SMELL-S (v2) (percentage±95% confidence interval). Theoptimal cut-off score for olfactory dysfunction defined by Youden'sIndex (center) is indicated by the blue dot. (D) Comparison of UPSIT andSMELL-R (v2) scores for Experiment 2 subjects (mean±S.D.) Subjects weredivided into dysfunctional (n=7) and normal (n=26) using an UPSITcut-off score of 29. Data labeled with different letters aresignificantly different (p=0.0035, two-sided unpaired t-test withWelch's correction). Subject Expt 2-A006 had a self-reported normalsense of smell but low scores on the UPSIT, as well as SMELL-S (v2) in Aand SMELL-R (v2) in D. (F) Area under the ROC curve (AUC) for SMELL-R(v2). The optimal cut-off is indicated by the green dot. (F) Plots offour measures of diagnostic accuracy resulting from different cut-offscores for SMELL-R (v2) (rate or percentage±95% confidence interval).The optimal cut-off score for olfactory dysfunction defined by Youden'sIndex (center) is indicated by the green dot. Subjects with identicalvalues are indicated by superimposed open circles and an X, and retainthe specified color coding.

FIG. 5 shows addressing the problem of different prior olfactoryexperiences. (A) Experiment 3 design. (B) Performance of Taiwanese(n=36) (top) and North American (n=36) (bottom) subjects for individualUPSIT items, open bar bars indicate correct answers and solid barsindicate the most frequent incorrect answer. (CD) Histogram of NorthAmerican and Taiwanese subject scores for the UPSIT (C) and SMELL-R (v2)(D). (E) Cross-population comparison of UPSIT and SMELL-R (v2) (mean±95%confidence interval) for subjects in (C,D).

FIG. 6 shows SMELL-S (panel A) and SMELL-R (panel B) stimuli are stableover 4 months of testing. To calculate the stability of SMELL-S (panelA) and SMELL-R (panel B), the median and interquartile range of testingscore per study visit day were plotted. The slope of the data was fittedby linear regression, and analyzed for significant difference from aslope of zero, which would correspond to perfect stability across thetesting period. Stimuli for each test were freshly made only once at thebeginning of the study, stored at room temperature in a ventilated lab,and used throughout the study. Study visit days took place 2-3 times aweek. We tested 75 subjects who performed each one of the 4 tests twice.

DETAILED DESCRIPTION OF THE DISCLOSURE

Although claimed subject matter will be described in terms of certainembodiments, other embodiments, including embodiments that do notprovide all of the benefits and features set forth herein, are alsowithin the scope of this disclosure. Various changes may be made withoutdeparting from the scope of the disclosure.

Every numerical range given throughout this specification includes itsupper and lower values, as well as every narrower numerical range thatfalls within it, as if such narrower numerical ranges were all expresslywritten herein.

The disclosure includes all method steps and compositions of matterdescribed herein in the text figures and tables of this disclosure,including all such steps individually and in all combinations thereof.The disclosure includes all compositions of matter including but notnecessarily limited to every combination and sub-combination ofcompounds described herein, all dilutions of the compounds, all compoundmixtures, all compound ratios, and all combinations of compoundcombinations that may be provided in single containers, or more than onecontainer, and sets of compounds provided in single and separatecontainers. Containers are defined as the vehicle by which stimuli arepresented to the subject, and can comprise a solid or liquid formulationin a vial or jar; a scratch ‘n’ sniff scent strip; a solid or liquidformulation in a device that produces a vapor or aerosol of the stimuli.The stimuli can be delivered manually by the subjects manipulating thecontainer and sniffing, or digitally by a device that automaticallydelivers the stimuli to the subject. In embodiments, a mixture ofcompounds described herein can be provided in a semi-solid composition,including but not limited to a wax. In embodiments, mixtures that arepresent in, for example, a wax, can be provided as a component of adevice, such as a disk, or cartridge. In embodiments, the disclosureincludes a system comprising one or more disks or cartridges thatcomprise a mixture of compounds described herein in a liquid,semi-solid, or solid medium. In embodiments, the system allows forproduction and/or dissemination to a user of a vapor, such as in thepresence of a drift, such as an air drift.

The compound combinations can comprise or consist of any of thecompounds listed for any combination thereof, and my further includebuffers or diluents that, for example, do not impact the olfactorysystem of a subject undergoing testing using the compounds. Thedisclosure includes a proviso that any compound or combination ofcompounds can be excluded from the claims of this application or patent,including but not necessarily limited to those compounds disclosedherein as “excluded” wherein the exclusion is for any reason, includingbut not limited to lateralization score or intensity-matching, or acombination thereof. Compounds of this disclosure are provided withcompound identifiers (CID) which are the permanent identifier for aunique chemical structure as curated in PubChem, a project of theNational Center for Biotechnology Information (NCBI) of the USgovernment. All of the information in the associated PubChem databasefor each of the CIDs in this disclosures is incorporated herein byreference as of the filing date of this application or patent. Inembodiments, compositions comprising any combination of compoundsdescribed herein remain stable over a period of time, such as from sevendays, to at least a period of twelve months, including all days andintervals of days there between. In embodiments, the combinations ofcompounds are stored at room temperature and remain stable. Inembodiments, stability is determined by the combination of compoundsremaining suitable for using in a method described herein. In anembodiment, stability is determined as described for FIG. 6 , whichdemonstrates determining stability of SMELL-S (FIG. 6 , panel A) andSMELL-R (FIG. 6 , panel B) tests, by plotting the median andinterquartile range of testing score per study visit day. The slope ofthe data was fitted by linear regression (but other statistical methodsthat will be apparent to those skilled in the art could also be used)and analyzed for significant difference from a slope of zero, whichwould correspond to perfect stability across the testing period.

The disclosure includes measuring olfactory sensitivity, olfactoryresolution, and combinations thereof. Such measurements can be madeduring a single test, or over consecutive tests, which may be performedduring a single testing period, such as in a single day, or over aseries of testing periods. The tests may be performed by a health careprofessional, or may be conveniently self-administered by the user. Thetests thus involve methods for evaluating the olfactory function of anindividual. The methods generally comprise allowing a subject to nasallyinhale odorants from any combination of compounds and/or series ofcompound combinations described herein such that a determination of thesensitivity and/or the resolution capability of the olfactory functionof the individual is made. The disclosure includes assigning thresholdand/or score values to the olfactory function of the individual, asfurther described herein. In certain aspects the disclosure includesusing the compound combinations described herein to assess olfactoryfunction and generate one or more scores or other values that representolfactory sensitivity, olfactory resolution, and/or combinationsthereof. The disclosure includes use of control combinations ofcompounds and comparing perception of smell of test combinations toperception of smell to the control combinations.

In certain embodiments, the disclosures provides for integration of thetesting procedures described herein with adaptive software to developone or more thresholds and/or scores for olfactory sensitivity and/orresolution. Thus, embodiments of the disclosure can in part beimplemented by a device comprising a microprocessor running software toperform one or more calculations described herein. In embodiments, thedisclosure includes an application (i.e., an app) that can guide a userthrough one or a series of tests described herein, and whereby the testresults can be entered into the app and one or more threshold values orscores can be generated and presented to the user via a user interface.Such apps can be configured to run on a computer connected to a bar codescanner, or any mobile device, such as a mobile phone or a tablet thatcan scan a QR code with a camera. In an embodiment, the software/appinterfaces with a scent delivery device that controls the release of thestimuli, wherein the stimuli comprise a combination of compounds asdescribed herein. In embodiments, the disclosure comprises a distributedsystem in a networked environment.

In certain embodiments the invention facilitates determination of thelowest concentration of an odor stimulus that a subject can perceive,and thus provides for generating a value for olfactory sensitivity. Inalternative or complementary embodiments the invention facilitatesanalysis of a subject's ability to distinguish distinct smells from oneanother, and thus provides a value for olfactory resolution. Inembodiments, methods of the disclosure can comprise performance oftriangle tests. Triangle tests are known to those skilled in the art asa discriminative approach used in sensory science to determine thepresence or absence of a stimulus, and/or a difference between distinctsamples, such as by asking a subject to select one of three stimuli thatis different from the other two.

In certain aspects of this disclosure, subjects are tested using aseries of odorant combinations, which may or may not be presented usinga triangle test approach, to determine which of a series of testcombinations of odorants can be perceived using, for instance, serialdilutions of combinations of odorants, until a threshold is reachedwherein no smell can be perceived. In certain aspects of thisdisclosure, subjects are tested to determine which of a series of testcombinations of odorants are different from a reference combination,such as by removal or replacement of one or more odorants from a seriesof odorant combinations, until a threshold is reached, whereindifference in smell between a sample and a reference cannot be detected.

In an embodiment, a triangle test may comprise a test using threeunknown samples to determine whether or not an individual can determinewhich sample is distinct from the others, i.e., the individual isprovided samples XXY, which represents three compounds or combinationsof compounds or dilutions thereof, to the individual, and the individualis tested to determine whether or not the individual can identify Y asdistinct from samples XX.

Non-limiting embodiments of the disclosure are generally outlined inFIG. 1 , wherein panel A in FIG. 1 depicts an approach to determiningolfactory sensitivity, and wherein FIG. 1 , panel B, presents anapproach to determining olfactory resolution. All steps and combinationsof steps depicted in the figures of this disclosure are included withinits scope. All dilution values described herein, whether or not depictedin the figures, are encompassed within this disclosure. All possiblecombinations of compounds listed Supporting Data Set 1 and all othertables provided herein are encompassed by this disclosure. Any singlecompound, or any combination of compounds described herein, can beexcluded from the claims.

In embodiments the disclosure provides for determining a threshold scorethat is at least in part calculated using a reversal, wherein a reversalcomprises a change in the direction of the concentration used for thetest, i.e., the subject who is nasally inhaling samples with increasingconcentrations is subsequently provided a decreased concentration, orvice versa. In embodiments, more than one reversal point can be attainedin order to determine a threshold value. In certain embodiments, from1-7 reversals are attained. In embodiments, a threshold value isdetermined when a subject cannot detect a particular high concentrationof odorants at least twice, or the subject detects a particular lowconcentration of odorants more than one time. A threshold value can bethe same as, or used in establishing a score for the individual. In anembodiment, a score can be determined using reversals in combinationwith concentration values where one, or a series, or an average ofconcentration values where reversal(s) occurred are used. Inembodiments, an individual is assigned a score of from 1-16, wherein 16indicates the individual is able to correctly identify lowconcentrations of odorants, whereas a score of 1 indicates theindividual was not able to identify high concentrations of odorants.Such thresholds and scores can be used for determining olfactorysensitivity, and can be adapted for determining olfactory resolution.For example, standard staircase procedures can be used, given thebenefit of the present disclosure, to determine a subject's ability todiscriminate between different combinations of compounds that can be,for example, altered in a stepwise fashion to become increasinglysimilar or dissimilar to each other, and/or to test the capability of anindividual to detect a sample that is dissimilar from other sample(s),such as is generally outlined in FIG. 1B.

In certain approaches the compositions, kits and methods of thisdisclosure are broadly applicable to geographically and culturallydistinct populations of human individuals, and to individuals over avariety of ages. Thus, the disclosure removes difficulties of, forexample, semantic-based smell tests that include biases based on lack ofprior exposure to an odorant, and/or an inability to verbalize acharacteristic of an odorant due to geographical, cultural, orlinguistic influences or experience. In particular, the presentdisclosure provides smell tests that use mixtures of molecules thataverage out the variability in sensitivity to individual molecules.Because these mixtures have unfamiliar odors, and the tests arenon-semantic, their use eliminates differences in test performance dueto the familiarity with the smells or the words used to describe them.Thus, the tests facilitate smell testing of diverse populations, withoutthe need to adapt the test stimuli.

In certain approaches the compositions and methods of this disclosureare used to test a human individual who is diagnosed with, suspected ofhaving, or is at risk for developing one or more sensory and/orcognitive disorders. In embodiments, the individual is at risk fordeveloping a cognitive disorder that comprises memory loss, and/ordementia. In embodiments the disclosure is used to aid in diagnosis ofsuch a disorder, and may moreover contribute to earlier diagnosis thanhas been possible before the development of the present invention. Inembodiments the disorder is Alzheimer's disease, or is a post-concussionsyndrome, or Chronic Traumatic Encephalopathy (CTE). In certain andalternative embodiments, the disclosure aids in diagnosis of hyposmia,anosmia, parosmia, or phantosmia. Additional conditions that thecompositions and methods of this disclosure may assist in the diagnosisof include but are not necessarily limited to: inflammatory nasal andsinus diseases, such as those caused by postviral olfactory dysfunction,chronic rhinosinusitis with nasal polyps, chronic rhinosinusitis withoutnasal polyps; nasal tumors, including esthesioneuroblastoma,adenocarcinoma, respiratory epithelial adenomatoid hamartoma;neurodegenerative diseases including Parkinson's Disease andHuntington's Disease; normal aging; toxic exposure to chemicals in theindustrial workplace; congenital syndromes affecting the sense of smell,including Kallmann Syndrome, Kartagener Syndrome, Isolated CongenitalAnosmia; brain tumors, including olfactory groove meningioma or temporallobe neoplasia; systemic diseases, including diabetes, alcoholism, liverfailure, renal failure, hypothyroidism, systemic lupus erythematosus;and psychiatric disorders, including depression or schizophrenia. Thus,in embodiments, a result obtained from performing a method of thisdisclosure may provide a diagnosis, or aid in a healthcare provider'sdiagnosis, of any of the foregoing conditions.

In embodiments, the compositions and methods of this disclosure can aidin monitoring a treatment for one or more conditions. In a non-limitingembodiment, an individual can be evaluated with an initial test or setof tests described herein to establish baseline values for olfactorysensitivity and/or olfactory resolution. The individual can subsequentlybe re-tested after, for example, a period of therapy for a disorder, andif the individual exhibits an improvement in a value for olfactorysensitivity and/or olfactory resolution relative to the baseline it maybe indicative that the particular therapy is effective. Conversely, ifthe individual exhibits worsening of a value for olfactory sensitivityand/or olfactory resolution relative to the baseline it may beindicative that the particular therapy is not effective. Similarapproaches can be adapted to determine if, for example, a particularagent, such as pharmaceutical agent or environmental agent, is having animpact on the olfactory function of an individual. In other embodiments,the disclosure is suitable for evaluating whether an individual hassuitable olfactory properties that relate to, for example, a particularoccupation wherein sense of smell is important for safety or otherreasons, including but not necessarily limited to the development ofconsumer and industrial products that produce or otherwise involveperception of distinct odors.

In view of the foregoing and the following description, figures andtables, it will be apparent to those skilled in the art that the presentdisclosure provides new non-semantic tests for olfactory sensitivity(SMELL-S) and olfactory resolution (SMELL-R) that overcome previouschallenges by using mixtures of odorants that have unfamiliar smells.The tests can be self-administered with minimal training and exhibithigh test-retest reliability. Because SMELL-S uses odor mixtures ratherthan a single molecule, odor-specific insensitivity is averaged out.Indeed, SMELL-S accurately distinguished people with normal anddysfunctional smell. SMELL-R is a discrimination test in which thedifference between two stimulus mixtures can be altered stepwise. Thisis an advance over current discrimination tests, which ask subjects todiscriminate monomolecular odorants whose difference cannot beobjectively calculated. SMELL-R showed significantly less bias in scoresbetween North American and Taiwanese subjects than conventionalsemantically-based smell tests that need to be adapted and translated todifferent populations. It is expected that SMELL-S and SMELL-R will bebroadly effective in diagnosing smell dysfunction, including thatassociated with the earliest signs of memory loss in Alzheimer'sdisease.

In embodiments, compounds used during testing according to thisdisclosure are provided to the subject in identical containers, with theproviso that coded indicia signifying to the test provider may beincluded to identify the composition of the compounds. In embodiments,at least two containers, or at least three containers are provided. Atleast one of the containers comprises a distinct combination ofcompounds, and/or a distinct dilution of compounds, relative to at leastone other container. In embodiments, the containers are arranged in aparticular order, such as a line, and the subject nasally inhales thesample from left to right, or right to left, or top to bottom, or bottomto top, etc. In embodiments, the subject identifies strongest odor(SMELL-S, as described below) or the odd odor (SMELL-R, as describedbelow), or completes both tests.

In embodiments the disclosure provides combinations of the followingcompounds, which are also listed in the “Molecules Included” table thatis part of the Supporting Data Set 1 that forms a part of thisdisclosure: butyraldehyde, cuminaldehyde, octanal, dihydrocoumarin,octanol, phenethylamine, pyruvic acid, methyl sulfide,4-methyl-5-thiazoleethanol, decanoic acid, eugenol,2-phenylethanol,dimethyl anthranilate, 2-isopropylphenol, 2-methoxy-4-methylphenol,carvyl acetate, furfuryl alcohol, α-methylbenzyl alcohol, acetophenone,methyl phenylacetate, diphenyl ether, α,α-dimethylbenzenepropanol,phenethyl acetate, 2-ethyl-1-hexanol, 4-methylanisole, ethyl propionate,diethyl malonate, ethyl butyrate, propyl butyrate,3,7-dimethyl-1-octanol, (−)-citronellol, isoamyl butyrate, ethylheptanoate, ethyl octanoate, propyl propionate, dimethyl succinate,methyl heptanoate, gamma-valerolactone, benzenethiol, butyl butyrate,butylamine, thiophene, ethyl decanoate, diethyl sebacate, valeraldehyde,piperidine, 2-octanone, heptanoic acid, propyl sulfide, heptanol,decanol, lauryl acetate, 2-hydroxyacetophenone, methyl anthranilate,p-tolyl acetate, 4-allylanisole, ethyl acetate, allyl heptanoate,nonanol, α,α-dimethylphenethyl acetate, 3-acetylpyridine. diethylsulfide, 6-methyl-5-hepten-2-one, carvacrol, methyl propionate, butylpropionate, methyl 2-furoate, 5-methylfurfural, ethyl undecanoate,pentyl acetate, 2-decanone, 2-nonanone, decahydro-2-naphthol, undecane,1,6-hexanedithiol, 2-acetyl-5-methylfuran, Isoamyl octanoate, allylbutyrate, terpinyl formate, 2-methoxy-3-methylpyrazine, hexyl hexanoate,ethyl 2-methylbutyrate, phenethyl propionate, p-anisaldehyde, ethylhexanoate, allyl hexanoate, benzyl phenylacetate, 2-phenoxyethylisobutyrate, butyl 10-undecenoate, methyl 2-methoxybenzoate, hexylformate, 4-methyl-5-thiazoleethanol acetate, delta-undecalactone,ethyl-3-hydroxyhexanoate, 3-acetyl-2,5-dimethylfuran, 2-ethoxythiazole,2-furanmethanethiol formate, 4-oxoisophorone, dihydrojasmone, whiskeylactone, 6-acetyl-1,1,2,4,4,7-hexamethyltetralin,2-methyl-4-propyl-1,3-oxathiane, 2-acetyl-3,5(6)-dimethylpyrazine,omega-pentadecalactone, 3-octanone, phenethyl 2-furoate,2-(1-methylpropyl)thiazole, 3-octyl acetate, and geraniol.

These compounds were intensity-matched and exhibited a lateralizationscore≤11, as described further herein. In embodiments, the disclosureincludes combinations of that comprise or consist of at least 2, 3, 4,5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23,24, 25, 26, 27, 28, 29, or 30 of these compounds. Mixtures that includemore than 30 compounds, whether or not they are the compounds describedherein, are also included. In embodiments, the disclosure comprisescombinations of these compounds, wherein the compounds are divided intomore than one container. Any container suitable for holding thecompounds, and whereby a human subject can access the container to smellits contents, is included in the disclosures. In embodiments, thecontainer comprises a glass or plastic vessel which may comprise anattached or removal cover or cap. In embodiments the vessel is a jar, atube, or a vial. In embodiments, the vessel comprises an absorbentmaterial. In embodiments, the vessel comprises a digital scent deliverydevice that volatilizes or aerosolizes the stimuli from a solid orliquid form. In embodiments, the disclosure comprises combinations thatcontain all of compounds in the Molecules Included list below, whereinsets of the compounds, such as from 2-30 of the compounds, are dividedinto separate containers. In embodiments, the disclosures comprises setsof these compounds, wherein the compounds are diluted by a method and ina solvent appropriate for a given delivery system such as one or moredilutions obtained from a serial dilution.

In embodiments, the disclosure comprises any combination(s) or sets ofcombinations of compounds that are described in the “Table SMELL-R andSMELL-S Combinations” table that is part of the Supporting Data Set 1.In embodiments, one or more of the compounds are diluted as set forth inthe SMELL-R and SMELL-S Combinations table.

In embodiments, the disclosure comprises kits. The kits can comprise oneor more containers comprising any combination of compounds describedherein, and may comprise empty containers for iterative tests, and/orfor making compound dilutions for use in the methods described herein.The kits can include one or more solutions, such as for dissolving orsuspending or dispersing any of the compounds described herein, and/orfor diluting such compounds. The kits may comprise compound master mixesthat are suitable for use directly, or for making dilutions and compoundcombinations as described herein. The kits can include printed materialor a means for accessing web-hosted information that instructs the userhow to perform the sensitivity and/or resolution tests described herein.

In one embodiment, the disclosure comprises fixing one or more resultsfrom a test described herein in a tangible medium of expression, andoptionally communicating the test result to a database, and/or to ahealth care provider.

The following examples are intended to illustrate but not limit theinvention.

EXAMPLE 1

This example provides a description of smell tests: SMELL-S and SMELL-R.

To improve currently available diagnostic tools for testing olfactoryfunction, and as outlined above, we created two new smell tests based onodorant mixtures. The Olfactory Sensitivity Test (SMELL-S) measuressensitivity to a mixture of 30 monomolecular odorants (FIG. 1A). TheOlfactory Resolution Test (SMELL-R) measures the ability of subjects todiscriminate the smell of such mixtures with an increase in overlappingcomponents (FIG. 1B) (21, 22). Tests were presented in glass jars orvials as triangle tests, in which subjects were asked to pick out thestimulus with the strongest odor (SMELL-S) or the odd odor (SMELL-R).Both tests used adaptive staircase procedures that are standard inclinical olfactory testing (FIG. 1A, 1B) (23) (Hummel T, Sekinger B,Wolf S R, Pauli E, & Kobal G (1997) ‘Sniffin' sticks’: olfactoryperformance assessed by the combined testing of odor identification,odor discrimination and olfactory threshold. Chem Senses 22(1):39-52,the disclosure of which is incorporated herein by reference).

Test-Retest Reliability

Effective diagnostic tests should be designed with high test-retestreliability. We therefore measured the reliability of SMELL-S andSMELL-R in a population of subjects with a self-reported normal sense ofsmell (Experiment 1; FIG. 2A). We tested two versions of SMELL-S andSMELL-R (v1 and v2) which are described in the Supporting Data set whichis part of this disclosures, which differed in the 30 components usedfor the mixtures. We also carried out conventional threshold tests withthe monomolecular odorants phenylethyl alcohol and butanol. All testswere self-administered with stimuli presented in glass jars. We excludeddata from the butanol threshold test from analysis because the stimuliwere not stable, as evidenced by a decline in average daily score forall subjects over the course of the four-month study (Supporting DataSet 1).

To assess test-retest reliability for SMELL-S, we computed the absolutedifference in test-retest scores for each subject (FIG. 2B). The bias,as defined by the difference between the average of the test and retestscores, was close to zero for all three tests. This indicates thatsubjects did not show systematically different performance between thetest and retest sessions. The 95% limits of agreement were much smallerfor the two SMELL-S tests than the phenylethyl alcohol threshold test(FIG. 2B). We did not calculate test-retest correlations because of thelarge inter-individual variability of the phenylethyl alcohol thresholdtest compared to the two versions of SMELL-S (24). These resultsdemonstrate that the SMELL-S test is more reliable than the phenylethylalcohol threshold test. The phenylethyl alcohol threshold test iscommercially available as Sniffin' Sticks, a well-validated testadministered by clinical staff that utilizes felt-tip pens for odorantdelivery (23, 25). To confirm that our self-administered phenylethylalcohol threshold test presented in glass vials produced resultscomparable to Sniffin' Sticks, we re-invited 23 subjects from Experiment1 and administered the Sniffin Sticks' version of the phenylethylalcohol threshold test. There was a strong correlation between thephenylethyl alcohol threshold self-administered in glass vials andSniffin' Sticks administered by a research assistant (r=0.87; 95%confidence interval: 0.72-0.95, Pearson correlation). This furtherconfirms our conclusions that both versions of SMELL-S are more reliabletests of olfactory sensitivity than thresholds measured with phenylethylalcohol.

We next examined the test-retest reliability of the SMELL-R test.Because the interindividual variability between SMELL-R (v1) (mean9.3±4.3 standard deviation) and SMELL-R (v2) (mean 10.2±3.5 standarddeviation) did not differ significantly (p=0.074, F test) (FIG. 2C), wecalculated the intraclass correlation coefficient (ICC) for the SMELL-Rtests. By this metric the two versions of SMELL-R are very reliable(FIG. 2C). Because SMELL-R (v2) had lower interindividual variability,we used this version of the test for the remaining experiments in thestudy.

Addressing the Problem of Odor-Specific Insensitivity

Smell tests that use a monomolecular stimulus like phenylethyl alcoholmay misdiagnose a subject with odor-specific insensitivity to thisodorant. A test based on mixtures of many components would overcomesthis problem as described herein, because each odorant in the mixturehas only a small impact on the overall test score (26). Such a test isexpected to be highly effective in diagnosing general olfactorydysfunction, rather than variability in sensitivity to any individualodorant.

To explore how odor-specific sensitivity affects the accuracy of smelldysfunction diagnosis, we compared the performance of subjects inExperiment 1 on smell tests that used monomolecular stimuli or mixtures.The variability in test scores across all subjects in Experiment 1 ofthe phenylethyl alcohol threshold was significantly higher than that ofSMELL-S (v1) and SMELL-S (v2) (FIG. 3A). Of the 7 subjects in the lowest10^(th) percentile in the phenylethyl alcohol threshold test, only onewas in the lowest 10^(th) percentile for both versions of SMELL-S.Without intending to be bound by any particular theory, we speculatethat this subject has an impaired sense of smell. The low phenylethylalcohol scores of the other 6 subjects likely reflect odor-specificinsensitivity to odorant rather than impaired olfactory function. Thesesubjects would have been misdiagnosed with smell dysfunction using thephenylethyl alcohol threshold test.

To confirm this, we compared the SMELL-S test with the Sniffin' Sticksphenylethyl alcohol threshold test and the North American version of theUPSIT (Experiment 2; FIG. 3B). Since SMELL-S (v2) had the narrowest 95%limits of agreement (FIG. 2B), we used this version of SMELL-S for therest of this study. In Experiment 2, we assessed the performance ofsubjects with a self-reported normal or abnormal sense of smell on theUPSIT, Sniffin' Sticks, and SMELL-S (v2). Based on results in FIG. 3A,we anticipated that SMELL-S (v2) would be more accurate than theSniffin' Sticks phenylethyl alcohol threshold test in identifyingsubjects with smell dysfunction. We used the UPSIT to benchmark theperformance of the Sniffin' Sticks phenylethyl alcohol threshold testcompared to SMELL-S (v2). Because this smell test is composed of 40different items, the final score is not strongly affected byodor-specific insensitivity to any given stimulus among the 40 items ofthe test. To set a cut-off between normal and dysfunctional subjects, weperformed a literature search on mean UPSIT scores in North Americanpatients suffering from smell dysfunction caused by various etiologies.Based on this analysis and consistent with an earlier study (3), wedefined normal olfactory function as an UPSIT score of 29 and over andsmell dysfunction as an UPSIT score of 28 and lower (FIG. 3C). InExperiment 2, the mean score of the subjects with self-reported smelldysfunction was below this cut-off, whereas the mean score of those withself-reported normal sense of smell was above the cut-off (FIG. 3C). Forthe Sniffin' Sticks phenylethyl alcohol threshold test we used thecut-off specified by the manufacturer, with normal defined as a scorehigher than 6.5 and dysfunctional a score of lower than 6.5.

Subjects in Experiment 2 were divided into normal and dysfunctionalaccording to their performance on the Sniffin' Sticks phenylethylalcohol threshold test (FIG. 3D). Using the UPSIT cut-off score as ametric of olfactory dysfunction, 10 subjects would have beenmisdiagnosed as having olfactory dysfunction by the Sniffin' Sticksphenylethyl alcohol threshold test (FIG. 3D-G, red dots). When wedivided subjects according to performance on the SMELL-S (v2) test usinga cut-off score of 7 (see FIG. 4 ), we found that only one subject wasgiven a different diagnosis using the UPSIT than with SMELL-S (v2) (FIG.3F). This demonstrates that the SMELL-S (v2) test is superior to theSniffin' Sticks phenylethyl alcohol threshold test in accuratelydiagnosing smell dysfunction. We conclude that odor-specificinsensitivity to phenylethyl alcohol makes the Sniffin' Sticksphenylethyl alcohol threshold unreliable, and that the use of odormixtures in SMELL-S (v2) overcomes this problem and is superior inaccurately diagnosing smell dysfunction.

Diagnostic Accuracy

To be useful in the clinic, smell tests should correctly identifypatients with smell dysfunction, and not misdiagnose normal subjects. Inother words, diagnostic tests must balance false positive and falsenegative results. To establish a diagnostically optimal cut-off scorefor SMELL-S (v2) and SMELL-R (v2), we divided subjects intodysfunctional and normal using an UPSIT cut-off score of 29, andexamined SMELL-S (v2) scores of self-reported normal and abnormalsubjects in these two groups (FIG. 4A). Subjects with normal UPSITscores had significantly higher SMELL-S (v2) scores than those that weredysfunctional (FIG. 4A). Subjects with a self-reported normal sense ofsmell (blue dots in FIG. 4A) had significantly higher SMELL-S (v2)scores (median, 12.5; interquartile range, 11-14) than whose withself-reported abnormal sense of smell (median, 7.75; interquartilerange, 2.25-9.50) (red dots in FIG. 4A) (p=0.0011, Mann-Whitney test).

We next determined the overall accuracy of SMELL-S (v2), and selected anoptimal cut-off score to differentiate normal and dysfunctional subjects(FIG. 4B-C). The standard measure of clinical test accuracy is the areaunder the receiver operating characteristic (ROC) curve, which plots thetrue and false positive rates at different cut-off scores. The areaunder the ROC curve of SMELL-S (v2) is 0.98 (95% confidence interval:0.85-1.00) (FIG. 4B), which is close to the perfect accuracy of 1.

To select the cut-off value for SMELL-S (v2) that optimallydistinguishes normal and dysfunctional subjects we calculated Youden'sIndex (27) at each of 14 SMELL-S (v2) cut-off scores. A Youden's Indexvalue of 1 indicates no false positives and no false negatives. (FIG.4C). Based on this analysis, the administration of SMELL-S (v2) with acut-off value of 7 will be clinically useful for physicians to diagnosepatients with olfactory dysfunction.

We carried out the same procedure to determine the accuracy of theSMELL-R olfactory resolution test. Subjects classified as dysfunctionalby their UPSIT score had lower SMELL-R (v2) scores, and subjectsclassified as normal by UPSIT performance had a higher SMELL-R (v2)scores (FIG. 4D). The area under the ROC curve for SMELL-R (v2) was 0.82(95% confidence interval: 0.65-0.93) (FIG. 4E). The optimal cut-offassessed by Youden's Index was 8.5 (FIG. 4F). These data show thatSMELL-R at a cut-off value of 8.5 will be clinically useful fordiagnosing smell dysfunction.

Addressing the Problem of Different Prior Olfactory Experiences

An aspect of this disclosure is the development of a test that does nothave to be adapted to different populations. To ask if SMELL-R (v2)performs well in different countries, we compared SMELL-R (v2)performance between Taiwanese and North American subjects (Experiment 3,FIG. 5A). As a positive control we used the North American version ofthe UPSIT for both populations, because previous work has shown thatTaiwanese subjects have systematically lower scores on this test due tounfamiliarity with several of the test items (18). To enableself-administration of the UPSIT we supplied Taiwanese subjects with aChinese translation of the English multiple-choice questions in the testbooklet. SMELL-R (v2) did not require any language translation becauseit is non-semantic.

North Americans performed better on most of the items in the UPSIT, withthe biggest differences found for “pine”, “lime”, “cherry”, and “rose”(FIG. 5B). Even so, several items were frequently mistaken by NorthAmerican subjects, including “paint thinner” when the correct answer was“cheddar cheese”, “musk” instead of “lime”, and “wintergreen” instead of“bubble gum”. The Taiwanese subjects also struggled with the “cheddarcheese” item, also frequently mistaking it for “paint thinner”, but inaddition mistook “turpentine” for “soap”, “motor oil” for “grass”, and“clove” for “licorice”. The overall UPSIT scores for Taiwanese subjectswere significantly lower than those of the North American subjects (FIG.5C) (p<0.0001, Mann Whitney test). In contrast, Taiwanese subjectsscored higher on SMELL-R (v2) than the North American subjects (FIG. 5D)(p=0.0157, Mann Whitney test). The difference for the two populationswas much smaller for SMELL-R (v2) than the UPSIT as determined bycalculating the difference in Z-scores (FIG. 5E). While we do not knowthe underlying cause for the superior performance of Taiwanese subjectson SMELL-R (v2), the results show that our test avoids the bias seen forthe UPSIT, in which test performance is systematically higher in thepopulation for which the test was developed. We conclude that SMELL-R(v2) can be applied across different populations with different priorolfactory experiences, and without the need to adapt it to the localculture and language.

Materials and Methods

General, Subjects

All behavioral testing with human subjects took place between March 2015and December 2016, and was approved and monitored by the InstitutionalReview Boards of The Rockefeller University in New York, NY (USA),except the Taiwanese arm of Experiment 3, which was approved by theInstitutional Review Board of Taichung Veterans General Hospital inTaichung, Taiwan. North American subjects were recruited by TheRockefeller University Clinical Research Recruitment and OutreachSupport Service (37). Taiwanese subjects were recruited by the nursingstaff of the Department of Otorhinolaryngology at the Taichung VeteransGeneral Hospital (Taiwan). All subjects gave their written informedconsent to participate in these experiments, and were compensated fortheir time. All North American and Taiwanese subjects were able tounderstand and follow instructions in English or Mandarin, respectively.Subjects were aged 18 or over and agreed to refrain from using perfumeor cologne, and ingesting anything except water one hour prior to thestudy visit. At the beginning of each visit, subjects washed their handswith odorless soap. For subjects reporting a normal sense of smell andtaste, we excluded subjects who presented with current or past historyof conditions that might be related to smell loss (acute or chronicrhinosinusitis, nasal tumor, upper respiratory tract infection or headtrauma that altered the sense of smell for more than one month, historyof brain or sinonasal surgery, asthma, stroke, neurodegenerativedisease, radiation therapy or chemotherapy, active smoking, orconsumption of medication affecting the sense of smell during thestudy). Participants with self-reported smell dysfunction were notsubject to these exclusion criteria. All raw data in the paper,including details about the demographics of the subjects, odorants, andcomposition of the test stimuli are in Supporting Data Set 1.

General, Tests

To allow for self-administration and automatic data collection, wedesigned a custom computer application that was used for the vialthreshold tests and also the SMELL-S and SMELL-R tests. The testingstation comprised a computer, wireless mouse, barcode scanner, and trayscontaining numbered stimulus containers labeled with bar codes. Triangletests were set up so that subjects were never tested with the same setof stimuli twice in a row, to avoid the situation where subjectsremembered their answers from the previous trial. Subjects used abarcode scanner to register test data automatically. Subjects tookbetween 20-35 minutes to complete each smell test, with the exception ofthe UPSIT which took 10-15 minutes. A standard inter-trial interval wasimposed to avoid odor adaptation by requiring subjects to play acomputer game for 20 seconds.

SMELL-S and SMELL-R were created with four different mixtures of 30molecules drawn from a panel of 109 monomolecular, intensity-matchedchemicals. These odorants were selected from stimuli utilized inprevious psychophysical studies (21, 38). We used only molecules thatminimally activated the trigeminal system, because such stimuli can bedetected by anosmic subjects (39, 40). A characteristic of trigeminalactivation by a molecule is a fresh, cold, burning, eucalyptus, pungent,or tickling sensation. We used a lateralization task in which an odorantis applied into only one nostril to assign a lateralization score toeach molecule. It is possible to localize the stimulated nostril if itactivates the trigeminal system. In contrast, it is much harder tolocalize an olfactory stimulus (41). Lateralization tasks wereself-administered by one investigator. Two disposable squeeze bottleswere placed in a device facilitating simultaneous squeezing and stimulidelivery in each nostril. Only one bottle was filled with an odorstimulus. The tip of each bottle was fitted with a foam piece thatconformed to the investigator's nostril, and placed at the entrance ofeach nostril. The investigator squeezed both bottles simultaneously andattempted to localize which nostril had received the stimulus. Aftereach task, the device was spun on a rotating platform to randomize theodor-stimulus side. The final score corresponded to the number ofcorrect tasks. There were a total of 20 tasks (42). As a controlexperiment, we found that the lateralization score of the trigeminalstimulus eucalyptol (CID: 2758) at pure concentration was high (median,20; interquartile range, 19.25-20; 4 trials). The lateralization scoreof the olfactory stimulus vanillin (CID: 1183) at pure concentration waslow (median, 6.5; interquartile range, 5-12.5, 6 trials). The differencebetween the lateralization scores of eucalyptol and vanillin wasstatistically significant (p=0.0009, Mann-Whitney test). Each candidatefor the mixtures was tested once. We included candidates with a score of11 and below in the design of the mixtures (Supporting Data Set 1).

To intensity-match molecules to be used in mixtures, odorants werediluted and three investigators individually classified them as “tooweak”, “well matched”, or “too strong”. The concentration of “too weak”stimuli was increased and that of “too strong” stimuli decreased by afactor of 10. Weak components that could not be intensity-matched evenat pure concentrations were excluded from the pool of odorants. Werepeated this process until most of the components fell into the optimalintensity range. For 18 components investigators could not reach aconsensus about intensity, but these were nevertheless used in themixtures (CID: 1068, 7969, 31244, 9589, 17898, 104721, 3314, 14491,62144, 7583, 7983, 60999, 251531, 7799, 61151, 9609, 8118, 89440). Withthese components, we created four mixtures of 30 components. The SMELL-S(v1) mixture was used as the ODD odor in SMELL-R (v1), and the SMELL-S(v2) mixtures was used as the CONTROL odor in SMELL R (v2). The mixturesfor SMELL-R (v1) CONTROL odor and SMELL-R (v2) ODD odor were unique tothese tests. Details of all mixtures are in Supporting Data Set 1.

Stimuli for the vial threshold tests and SMELL-S were presented tosubjects with amber glass vials (height: 95 mm, diameter: 28 mm).Stimuli for SMELL-R were presented to subjects with amber glass jars(height: 51 mm, diameter: 55 mm). The complete list of stimuli used inthis study is in Supporting Data Set 1.

Threshold Tests: Phenylethyl Alcohol and Butanol

Threshold tests were administered as a series of triangle tests.Subjects were presented with three vials: two contained 1 ml solvent(paraffin oil) and one contained either phenylethyl alcohol or butanoldiluted in solvent in a total volume of 1 ml. Tests comprised 16different concentrations generated by serial dilutions (1:2) of eitherodorant in paraffin oil, with the starting concentrations at 0.0313% forphenylethyl alcohol (vial) and 0.25% for butanol (vial). The subject wasprompted to sniff each vial and select the one with the strongestperceived odor using an adaptive staircase procedure commonly used insmell testing (23). If they were unable to detect any difference amongthe three vials, they were prompted to choose one at random. Theprocedure started at the lowest concentration. If they identified anincorrect vial, the second next higher concentration was presented andso on, until they identified the correct vial. If the subjectsidentified the correct vial, they were retested at the sameconcentration. If they identified the correct vial in this retest, theywere tested at the next lower concentration. If they identified anincorrect vial, they were tested at the next higher concentration. Areversal is when the direction in which the concentration is changedreverses. The procedure ended after the seventh reversal, or until thesubject failed the level with the highest concentration twice in row, orsucceeded with the lowest concentration level 5 times in row. Thethreshold was defined as the average of the concentrations at which thelast two reversals occurred. If the highest concentration were notcorrectly identified twice, the score was 1. If the lowest wasidentified 5 times in a row, the score was 16.

SMELL-S Olfactory Sensitivity Test (v1 and v2)

For SMELL-S (v1) and SMELL-S (v2), we prepared 19 serial dilutions inparaffin oil (1:2) of two different mixtures of 30 monomolecularodorants and used the last 16 dilutions, such that the tests ranged fromeasiest (level 1, 1:8 dilution) to most difficult (level 16, 1:262,144dilution). Subjects were asked to sniff 3 vials, one of which was filledwith 1 ml of a mixture of 30 components, and the other two were filledwith 1 ml of solvent (paraffin oil). Subjects were instructed to pickout the one vial with the strongest perceived odor. If they were unableto detect any difference among the three vials, they were prompted tochoose one at random. The procedure started at the lowest concentration(level 16). We calculated the SMELL-S sensitivity score following thesame adaptive staircase procedure described above. For each subject, wemeasured the olfactory sensitivity with two versions of the tests,SMELL-S (v1) and SMELL-S (v2), which differed only by the chemicalcomposition of the mixtures.

SMELL-R Olfactory Resolution Tests (v1 and v2)

For SMELL-R (v1) and SMELL-R (v2), we prepared 16 pairs of mixtures of30 monomolecular odorants that differ in how many components the twomixtures in the pair share from 0% (easiest; level 1) to 96.7% (mostdifficult; level 16). To create 16 levels of increasing overlappingcomponents, we randomly progressively replaced components of a mixtureof 30 molecules (we termed this the ODD odor), with components fromanother mixture of 30 components that did not change in compositionacross the levels (we termed this the CONTROL odor). Increasing thelevel of difficulty by one point correspond to an addition of 2overlapping molecules between both mixtures, except from level 15 to 16,where we added only 1 shared molecule. Stimuli (8 ml) were introducedinto jars containing absorbent cotton pads. Subjects were asked to sniffthe contents of 3 jars, one of which was filled with 8 ml of a mixtureof 30 components, and the other two were filled with 8 ml of a mixtureof 30 components with different degree of overlap with the first jar.Subjects were instructed to pick out the odd jar. If they were unable todetect any difference among the three jars, they were prompted to chooseone at random. Triangle tests started at a medium difficulty (level 8).If they identified the incorrect jar, the next easier level waspresented. We calculated the SMELL-R resolution score following the sameadaptive staircase procedure described above. For each subject, wemeasured the olfactory resolution with two versions of the tests,SMELL-R (v1) and SMELL-R (v2), which differed only in the chemicalconstituents of the two sets of mixtures.

Sniffin' Sticks Phenylethyl Alcohol Threshold Test

The Sniffin' Sticks (23) threshold phenylethyl alcohol threshold test isa commercial product that uses felt-tip pens filled with odorant insteadof ink for odor presentation. [threshold module (2-phenyl ethanol) ofthe extended Burghart Sniffin' Sticks test, Burghart Messtechnik, item#LA-13-00015]. The test comprises pens containing 16 serial dilutions ofphenylethyl alcohol (1:2) in solvent (propylene glycol) with a startingconcentration of 4%. The test was administered as a triangle test. Threepens were presented to the subjects by the investigator in a randomizedorder. Two pens contained the solvent only, and the third pen containedthe diluted odorant. Subjects were blindfolded with a disposable maskbecause the color code of the Sniffin' Sticks reveals which pen containsthe odor, and were asked to identify the pen with the strongestperceived odor. The procedure started at the lowest or second lowestconcentration of odorant (level 16 or 15, respectively). We calculatedthe threshold score following the same adaptive staircase proceduredescribed above except that the threshold was defined as the average ofthe last four reversals occurred.

UPSIT

The University of Pennsylvania Smell Identification Test (UPSIT,marketed as the Smell Identification Test by Sensonics International) isa well-validated and self-administered smell identification test widelyused in the USA (43). The test consists of 4 different 10-page booklets,with a total of 40 monomolecular stimuli. On each page, there is adifferent “scratch and sniff” strip which is embedded with amicroencapsulated odorant. There are also four choice multiple-choicequestions on each page. Subjects used the tip of a pencil to release thesmell of the stimuli. Subjects sniffed the odorant and selected the oneword among the four options (for example “paint thinner”, “cherry”,“coconut”, or “cheddar cheese”) that most closely matched theirperception of the smell. Subjects entered their answers to the 40multiple-choice questions manually into a booklet, and investigatorstransferred the data manually into a spreadsheet. UPSIT performance wasscored as the number of correct answers out of 40. We used the sameNorth American UPSIT (43) on subjects at Rockefeller University andTaichung Veterans General Hospital. The Taiwanese subjects were given areference sheet on which the English multiple-choice questions in theUPSIT booklets were translated into Chinese by R.-S. J. (FIG. 5B) (18).

Experiment 1, Design

In this protocol (Rockefeller University IRB Protocol #JHS-0862), westudied the test-retest reliability of SMELL-S and SMELL-R. We invitedvolunteers with self-reported normal sense of smell and taste to theRockefeller University Hospital for six visits (FIG. 2A). During thesesix visits, six olfactory tests were performed, each of them once duringa test session (visit 1 to 3), and then again during a retest session(visit 4 to 6). There was a gap of at least 1 week between the last testvisit (visit 3) and the first retest visit (visit 4), and a gap of atleast 24 hours between each of the other visits. At each visit, two ofthe six tests were performed. Although the order of the tests wasrandomized, in any visit where SMELL-R tests were administered, theywere always administered after the SMELL-S or the threshold tests. Thisexperiment was done between March and June 2015.

Experiment 1, Subjects

75 subjects (43 female) participated in this experiment, with a mean ageof 44 (range: 21-74). 34 subjects self-identified as White, 26 as Black,6 as Asian, 2 as Mixed Race, and 7 as Other. 11 subjects self-identifiedas Hispanic. It took an average of 21 days (range: 14-38 days) forsubjects to complete all 6 visits in this experiment.

Experiment 1, Statistical Analysis

The Intra-class Correlation Coefficient (ICC) was used to measureabsolute agreement between test and retest measures for the wholecohort. A sample of n=75 subjects provided 95% confidence that the ICCin the population was larger than 0.67 based on a sample distributionthat is centered on 0.8 (44). Bland-Altman plots were used as anauxiliary tool if significant differences in inter-individualvariability were found between compared tests (24) (FIG. 2B). We usedthe non-parametric Conover squared ranks test to assess equality ofvariance across threshold tests. Statistical significance was reachedwhen p<0.05 (FIG. 3A).

Experiment 2, Design

This experiment was carried out under Rockefeller University IRBprotocol #JHS-0922, and was designed to evaluate the accuracy of ourtests and whether SMELL-S can distinguish between subjects withspecific-anosmia to phenylethyl alcohol but an otherwise normal sense ofsmell and subjects with smell dysfunction. During a single visit inDecember 2016, subjects performed four smell tests. The first two testswere either SMELL-S (v2) or Sniffin' Sticks phenylethyl alcoholthreshold test. The order of these first two tests was randomized. Itwas followed by SMELL-R (v2) and finally the UPSIT, as a validatedcommercial reference test. The investigators enforced a break of atleast 3 minutes between tests. During some of the breaks, participantsfilled out a questionnaire to provide demographic information and answerquestions about their sense of taste and smell (Supporting Data Set 1).In 7 cases in the UPSIT tests in Experiment 2, subjects did not providean answer to a given item, and this was scored as an incorrect answer.The missing data correspond to 3 subjects who missed one item each, and2 subjects who missed 2 items each.

Experiment 2, Subjects

This experiment included 33 subjects (22 female), with a mean age of 48(range: 21-76). 17 subjects self-identified as White, 8 as Black, 3 asAsian, 2 as Mixed Race, 1 as Other. Two subjects opted out ofself-reporting race. Four subjects self-identified as Hispanic. Were-enrolled 23 subjects from Experiment 1 who self-reported a normalsense of smell and taste. These 23 were selected based on theirthreshold test results to have approximately even representation ofsubjects with low, medium, and high sensitivity to phenylethyl alcohol.In addition, we recruited 10 subjects with self-reported smelldysfunction. The self-reported etiologies are reported in SupportingData Set 1.

Experiment 2, Statistical Analysis

We performed a power analysis and determined that a study with 32subjects (8 with smell loss and 24 with a normal sense of smell)guarantees 80% power at 5% significance to detect an area under the ROCcurve greater than 0.78. Since our actual study included 33 subjects, wecarried out a post hoc power analysis using the parameters above to showthat we can detect an area under the ROC curve greater than 0.79. Weemployed Youden's Index (27) to find the best cut-off score for SMELL-Sand SMELL-R to maximize correct classification of the olfactorysensitivity and resolution of a subject, respectively (FIG. 4C,F). Weused two-sided unpaired t-test with Welch's correction to test fordifferences between SMELL-S and SMELL-R score in normal anddysfunctional groups (FIG. 4A,C).

Experiment 3, Design

In this experiment, we investigated how SMELL-R performs on differentpopulations by comparing Taiwanese (IRB TCVGH #CE16119B) and NorthAmerican (Rockefeller University IRB Protocol #JHS-0901) subjects. TheNorth American subjects were tested at The Rockefeller UniversityHospital, and the Taiwanese subjects were tested in the Department ofOtolaryngology at Taichung Veterans General Hospital. The experimentaldesign was the same in both institutions. Each subject came to the testsite for a single visit, during which subjects performed the SMELL-R(v2) and UPSIT, separated by a 10 minute break, in randomized order(FIG. 5A).

Experiment 3, Subjects

36 subjects were recruited at both sites. All subjects were born andraised in their respective country, had never travelled to the oppositecountry, and had a self-reported normal sense of smell and taste. In theNorth American group, the mean age was 25 (range: 19-30), 23 of 36subjects were female, and 8 self-identified as White, 14 as Black, 4 asAsian, 9 as Mixed Race, and 1 as American Indian or Alaska native. Sixself-identified as Hispanic. In the Taiwanese group, the mean age was 26(range: 19-30) and 26 of 36 subjects were female. Although we recruitedsubjects with a self-reported normal sense of smell, two of the NorthAmerican subjects had UPSIT and SMELL-R (v2) scores below the cut-offfor olfactory dysfunction (FIG. 5C,D).

Experiment 3, Statistical Analysis

We used unpaired t-test with Welch's correction to test for differencesbetween smell test performance between North American and Taiwanesesubjects (FIG. 5C,D). These tests were applied with and without the 2North American subjects with UPSIT scores below the cut-off defined fora normal sense of smell.

Statistical Analysis

Normality of data was tested throughout using the Kolmogorov—Smirnovtest, and the appropriate statistics were used according to thedistribution of the data. SPSS (IBM) and Prism (Graphpad) was used forall statistical analysis.

“INCLUDED and EXCLUDED MOLECULES” (Supporting Data Set 1)

Molecules INCLUDED (n = 109): intensity- matched and lateralizationscore ≤11 CID Odor name 261 butyraldehyde 326 cuminaldehyde 454 octanal660 dihydrocoumarin 957 octanol 1001 phenethylamine 1060 pyruvic acid1068 methyl sulfide 1136 4-methyl-5-thiazoleethanol 2969 decanoic acid3314 eugenol 6054 2-phenylethanol 6826 dimethyl anthranilate 69432-isopropylphenol 7144 2-methoxy-4-methylphenol 7335 carvyl acetate 7361furfuryl alcohol 7409 α-methylbenzyl alcohol 7410 acetophenone 7559methyl phenylacetate 7583 diphenyl ether 7632α,α-dimethylbenzenepropanol 7654 phenethyl acetate 77202-ethyl-1-hexanol 7731 4-methylanisole 7749 ethyl propionate 7761diethyl malonate 7762 ethyl butyrate 7770 propyl butyrate 77923,7-dimethyl-1-octanol 7793 (−)-citronellol 7795 isoamyl butyrate 7797ethyl heptanoate 7799 ethyl octanoate 7803 propyl propionate 7820dimethyl succinate 7826 methyl heptanoate 7921 gamma-valerolactone 7969benzenethiol 7983 butyl butyrate 8007 butylamine 8030 thiophene 8048ethyl decanoate 8049 diethyl sebacate 8063 valeraldehyde 8082 piperidine8093 2-octanone 8094 heptanoic acid 8118 propyl sulfide 8129 heptanol8174 decanol 8205 lauryl acetate 8375 2-hydroxyacetophenone 8635 methylanthranilate 8797 p-tolyl acetate 8815 4-allylanisole 8857 ethyl acetate8878 allyl heptanoate 8914 nonanol 9024 α,α-dimethylphenethyl acetate9589 3-acetylpyridine 9609 diethyl sulfide 9862 6-methyl-5-hepten-2-one10364 carvacrol 11124 methyl propionate 11529 butyl propionate 11902methyl 2-furoate 12097 5-methylfurfural 12327 ethyl undecanoate 12348pentyl acetate 12741 2-decanone 13187 2-nonanone 13216decahydro-2-naphthol 14257 undecane 14491 1,6-hexanedithiol 145142-acetyl-5-methylfuran 16255 Isoamyl octanoate 16324 allyl butyrate16537 terpinyl formate 17898 2-methoxy-3-methylpyrazine 22873 hexylhexanoate 24020 ethyl 2-methylbutyrate 31225 phenethyl propionate 31244p-anisaldehyde 31265 ethyl hexanoate 31266 allyl hexanoate 60999 benzylphenylacetate 61005 2-phenoxyethyl isobutyrate 61027 butyl10-undecenoate 61151 methyl 2-methoxybenzoate 61177 hexyl formate 611924-methyl-5-thiazoleethanol acetate 61204 delta-undecalactone 61293ethyl-3-hydroxyhexanoate 61527 3-acetyl-2,5-dimethylfuran 618092-ethoxythiazole 62144 2-furanmethanethiol formate 62374 4-oxoisophorone62378 dihydrojasmone 62900 whiskey lactone 894406-acetyl-1,1,2,4,4,7-hexamethyltetralin 1010102-methyl-4-propyl-1,3-oxathiane 104721 2-acetyl-3,5(6)-dimethylpyrazine235414 omega-pentadecalactone 246728 3-octanone 251531 phenethyl2-furoate 519539 2-(1-methylpropyl)thiazole 521238 3-octyl acetate637566 geraniol

Molecules EXCLUDED (n = 73): lateralization score >11 CID Odor name 263butanol 379 octanoic acid 6050 tributyrin 6448 bornyl acetate 6501 ethyl3-methyl-3-phenylglycidate 6544 isophorone 6549 linalool 6753omega-6-hexadecenlactone 6998 salicylaldehyde 7047 quinoline 70596-methyl quinoline 7127 4-allyl-1,2-dimethoxy benzene 7136 eugenylacetate 7147 1-phenyl-1-propanol 7150 methyl benzoate 7165 ethylbenzoate 7194 phenethyl benzoate 7302 4-hydroxybutanoic acid lactone7519 anisole 7601 phenethyl phenyl acetate 7695 anisyl acetate 7824methyl caproate 7894 isoamylamine 8103 hexanol 8137 methyl 2-nonynoate8159 heptyl acetate 8163 2-undecanone 8294 linalyl acetate 8658o-anisaldehyde 8908 hexyl acetate 8918 nonyl acetate 10722o-tolualdehyde 10882 ethyl valerate 10890 amyl butyrate 10895 isobutylpropionate 11086 2-aminoacetophenone 11617 allyl sulfide 12178 3-hexanol12180 methyl butyrate 12206 methyl valerate 12265 2,5-dimethylpyrrole12377 dipropyl disulfide 12506 tetrahydrofurfuryl acetate 125874-methylvaleric acid 12810 delta-decalactone 12813 gamma-decalactone15606 methyl nonanoate 17617 allyl cyclohexanepropionate 184672-methoxypyrazine 18827 1-octen-3-ol 22386 2-pentanol 24197 diethylmalate 24513 decanal dimethyl acetal 24834 4-ethoxybenzaldehyde 274582,3-diethylpyrazine 31209 alpha-amylcinnamaldehyde 31210 butyl phenylacetate 31219 benzyl propionate 31234 3-phenyl-1-propanol 312522,5-dimethyl pyrazine 31404 butylated hydroxytoluene 368225,6,7,8-tetrahydroquinoxaline 60998 isobutyl phenyl acetate 61408 allyl2-ethylbutyrate 61641 methyl 3-(methylthio)propionate 62089(±)-4-methyloctanoic acid 440967 (−)-beta-pinene 520108 2-acetylthiazole565690 menthyl isovalerate 637758 ethyl cinnamate 637796 isosafrole643820 nerol 5281168 2-hexenal

Molecules EXCLUDED (n = 39): lateralization score ≤11 butintensity-matching failed CID Odor name 753 glycerol 1030 propyleneglycol 1183 vanillin 6506 tri ethyl citrate 6989 thymol 7360tetrahydrofurfuryl alcohol 7635 2-ethylhexyl acetate 7657 benzyl ether7937 2,6-dimethylpyridine 7991 valeric acid 8038 isobutyl acetate 8091methyl caprylate 8180 undecanoic acid 8184 1-undecanol 8186 undecanal8193 lauryl alcohol 8363 benzyl salicylate 9025 1,3-dimethoxybenzene10430 isovaleric acid 13204 delta-hexalactone 14286 2-acetyl pyridine15654 4-methyl-5-vinylthiazole 15717 allyl phenylacetate 17525 hexylbutyrate 21363 cyclohexaneacetic acid 26331 2-ethyl pyrazine 274572-ethyl-3-methylpyrazine 32594 2-isobutyl-3-methoxypyrazine 611384-pentenoic acid 61523 5-phenyl-1-pentanol 61670 5-methylquinoxaline62375 benzaldehyde dimethyl acetal 62444 methyl thiobutyrate 62572ethyl-3-hydroxybutyrate 93375 trivertal 228769 octyl isovalerate 440917d-limonene 520296 delta-tetradecalactone 595928 benzaldehyde propyleneglycol acetal

SMELL-S and SMELL-R: olfactory tests not influenced by odor-specificinsensitivity or prior olfactory experience

“SMELL-R MIXTURES”

SMELL-R (v1) CID Odor name Dilution first mix 145142-acetyl-5-methylfuran 1/1000  first mix 12741 2-decanone 1/10   firstmix 7720 2-ethyl-1-hexanol 1/1,000 first mix 13187 2-nonanone 1/100 first mix 6054 2-phenylethanol 1/100  first mix 894406-acetyl-1,1,2,4,4,7- 1/10   hexamethyltetralin first mix 7410acetophenone 1/1,000 first mix 16324 allyl butyrate 1/1000  first mix261 butyraldehyde 1/1,000 first mix 10364 carvacrol 1/1000  first mix7335 carvyl acetate 1/1000  first mix 2969 decanoic acid 1/10   firstmix 660 dihydrocoumarin 1/100  first mix 62378 dihydrojasmone 1/10  first mix 6826 dimethyl anthranilate 1/100  first mix 7583 diphenylether 1/1,000 first mix 24020 ethyl 2-methylbutyrate 1/1000  first mix12327 ethyl undecanoate 1/10   first mix 61293 ethyl-3-hydroxyhexanoatepure first mix 3314 eugenol 1/1,000 first mix 7921 gamma-valerolactone1/100  first mix 8094 heptanoic acid 1/10   first mix 8129 heptanol1/1000  first mix 7795 isoamyl butyrate 1/10   first mix 1068 methylsulfide 1/1,000 first mix 8914 nonanol pure first mix 31225 phenethylpropionate 1/100  first mix 1001 phenethyl amine 1/1,000 first mix 8030thiophene 1/1000  first mix 9024 α,α-dimethylphenethyl 1/10   acetatesecond mix 519539 2-(1-methylpropyl)thiazole  1/10,000 second mix 83752-hydroxyacetophenone 1/1,000 second mix 6943 2-isopropylphenol 1/1,000second mix 7144 2-methoxy-4-methylphenol  1/100,000 second mix 1010102-methyl-4-propyl-1,3-oxathiane  1/100,000 second mix 8093 2-octanone1/1,000 second mix 521238 3-octyl acetate 1/10   second mix 11364-methyl-5-thiazoleethanol 1/1,000 second mix 7731 4-methylanisole1/1,000 second mix 12097 5-methylfurfural 1/1,000 second mix 31266 allylhexanoate 1/1,000 second mix 7969 benzenethiol  1/100,000 second mix60999 benzyl phenyl acetate 1/100  second mix 7983 butyl butyrate1/1,000 second mix 8007 butylamine  1/10,000 second mix 13216decahydro-2-naphthol 1/1,000 second mix 8174 decanol 1/10   second mix61204 delta-undecalactone pure second mix 61177 hexyl formate 1/1,000second mix 22873 hexyl hexanoate 1/10   second mix 61151 methyl2-methoxybenzoate 1/100  second mix 7826 methyl heptanoate 1/1,000second mix 7559 methyl phenylacetate 1/1,000 second mix 11124 methylpropionate 1/1,000 second mix 454 octanal 1/1,000 second mix 957 octanol1/10   second mix 251531 phenethyl 2-furoate 1/100  second mix 7770propyl butyrate 1/1,000 second mix 1060 pyruvic acid  1/10,000 secondmix 8063 valeraldehyde  1/10,000

SMELL-R (v2) CID Odor name Dilution first mix 7793 (−)-citronellol1/10   first mix 104721 2-acetyl-3,5(6)- 1/1,000 dimethylpyrazine firstmix 61809 2-ethoxythiazole  1/10,000 first mix 178982-methoxy-3-methylpyrazine  1/100,000 first mix 61005 2-phenoxyethylisobutyrate pure first mix 9589 3-acetylpyridine 1/1,000 first mix246728 3-octanone 1/1,000 first mix 1136 4-methyl-5-thiazoleethanol1/1,000 first mix 61192 4-methyl-5-thiazoleethanol 1/1,000 acetate firstmix 9862 6-methyl-5-hepten-2-one 1/1,000 first mix 61027 butyl10-undecenoate pure first mix 11529 butyl propionate 1/1,000 first mix660 dihydrocoumarin 1/100  first mix 7820 dimethyl succinate 1/10  first mix 8857 ethyl acetate 1/1,000 first mix 7762 ethyl butyrate1/1,000 first mix 31265 ethyl hexanoate 1/100  first mix 7799 ethyloctanoate pure first mix 7749 ethyl propionate 1/1,000 first mix 12327ethyl undecanoate 1/10   first mix 16255 Isoamyl octanoate 1/10   firstmix 11902 methyl 2-furoate 1/1,000 first mix 454 octanal 1/1,000 firstmix 7654 phenethyl acetate 1/10   first mix 8082 piperidine  1/10,000first mix 8118 propyl sulfide  1/100,000 first mix 8797 p-tolyl acetate1/1,000 first mix 14257 undecane pure first mix 62900 whiskey lactone1/1,000 first mix 7632 α,α-dimethylbenzenepropanol 1/10   second mix14491 1,6-hexanedithiol  1/100,000 second mix 145142-acetyl-5-methylfuran 1/1000  second mix 62144 2-furanmethanethiolformate    1/1,000,000 second mix 7792 3,7-dimethyl-1-octanol 1/1,000second mix 61527 3-acetyl-2,5-dimethylfuran  1/10,000 second mix 88154-allylanisole 1/1,000 second mix 62374 4-oxoisophorone 1/100  secondmix 16324 allyl butyrate 1/1,000 second mix 8878 allyl heptanoate 1/100 second mix 326 cuminaldehyde 1/1,000 second mix 7761 diethyl malonate1/100  second mix 8049 diethyl sebacate pure second mix 9609 diethylsulfide  1/100,000 second mix 24020 ethyl 2-methylbutyrate 1/1000 second mix 8048 ethyl decanoate 1/10   second mix 7797 ethyl heptanoate1/100  second mix 7361 furfuryl alcohol 1/1,000 second mix 637566geraniol 1/10   second mix 8205 lauryl acetate 1/10   second mix 61151methyl 2-methoxybenzoate 1/100  second mix 8635 methyl anthranilate1/100  second mix 7826 methyl heptanoate 1/1,000 second mix 235414omega-pentadecalactone 1/10   second mix 31244 p-anisaldehyde 1/1,000second mix 12348 pentyl acetate 1/1,000 second mix 1001 phenethylamine1/1,000 second mix 7770 propyl butyrate 1/1,000 second mix 7803 propylpropionate 1/1,000 second mix 16537 terpinyl formate 1/1,000 second mix7409 α-methylbenzyl alcohol 1/100 

SMELL-S and SMELL-R: olfactory tests not influenced by odor-specificinsensitivity or prior olfactory experience

“SMELL-S MIXTURES”

SMELL-S (v1) CID Molecule Dilution 14514 2-acetyl-5-methylfuran  1/100012741 2-decanone 1/10 7720 2-ethyl-1-hexanol   1/1,000 13187 2-nonanone 1/100 6054 2-phenylethanol  1/100 894406-acetyl-1,1,2,4,4,7-hexamethyltetralin 1/10 7410 acetophenone   1/1,00016324 allyl butyrate  1/1000 261 butyraldehyde   1/1,000 10364 carvacrol 1/1000 7335 carvyl acetate  1/1000 2969 decanoic acid 1/10 660dihydrocoumarin  1/100 62378 dihydrojasmone 1/10 6826 dimethylanthranilate  1/100 7583 diphenyl ether   1/1,000 24020 ethyl2-methylbutyrate  1/1000 12327 ethyl undecanoate 1/10 61293ethyl-3-hydroxyhexanoate pure 3314 eugenol   1/1,000 7921gamma-valerolactone  1/100 8094 heptanoic acid 1/10 8129 heptanol 1/1000 7795 isoamyl butyrate 1/10 1068 methyl sulfide   1/1,000 8914nonanol pure 31225 phenethyl propionate  1/100 1001 phenethyl amine  1/1,000 8030 thiophene  1/1000 9024 α,α-dimethylphenethyl acetate 1/10

SMELL-S (v2) CID Molecule Dilution 14491 1,6-hexanedithiol  1/100,00014514 2-acetyl-5-methylfuran 1/1000  62144 2-furanmethanethiol formate   1/1,000,000 7792 3,7-dimethyl-1-octanol 1/1,000 615273-acetyl-2,5-dimethylfuran  1/10,000 8815 4-allylanisole 1/1,000 623744-oxoisophorone 1/100  16324 allyl butyrate 1/1,000 8878 allylheptanoate 1/100  326 cuminaldehyde 1/1,000 7761 diethyl malonate 1/100 8049 diethyl sebacate pure 9609 diethyl sulfide  1/100,000 24020 ethyl2-methylbutyrate 1/1000  8048 ethyl decanoate 1/10   7797 ethylheptanoate 1/100  7361 furfuryl alcohol 1/1,000 637566 geraniol 1/10  8205 lauryl acetate 1/10   61151 methyl 2-methoxybenzoate 1/100  8635methyl anthranilate 1/100  7826 methyl heptanoate 1/1,000 235414omega-pentadecalactone 1/10   31244 p-anisaldehyde 1/1,000 12348 pentylacetate 1/1,000 1001 phenethyl amine 1/1,000 7770 propyl butyrate1/1,000 7803 propyl propionate 1/1,000 16537 terpinyl formate 1/1,0007409 α-methylbenzyl alcohol 1/100 

SMELL-S and SMELL-R: olfactory tests not influenced by odor-specificinsensitivity or prior olfactory experience

“SMELL-S DILUTION RATIO”

SMELL-S (v1) Dilution ratio not used 1:1*  not used 1:2   not used 1:4  Level 1 1:8   Level 2 1:16  Level 3 1:32  Level 4 1:64  Level 5 1:128 Level 6 1:256  Level 7 1:512  Level 8 1:1024 Level 9 1:2048 Level 101:4096 Level 11 1:8192 Level 12  1:16384 Level 13  1:32768 Level 14 1:65536 Level 15  1:131072 Level 16  1:262144 *Dilution ratio 1:1corresponds to a mixture of 30 components of equal volume from the“SMELL-S mixtures”

SMELL-S (v2) Dilution Ratio not used 1:1*  not used 1:2   not used 1:4  Level 1 1:8   Level 2 1:16  Level 3 1:32  Level 4 1:64  Level 5 1:128 Level 6 1:256  Level 7 1:512  Level 8 1:1024 Level 9 1:2048 Level 101:4096 Level 11 1:8192 Level 12  1:16384 Level 13  1:32768 Level 14 1:65536 Level 15  1:131072 Level 16  1:262144 *Dilution ratio 1:1corresponds to a mixture of 30 components of equal volume from the“SMELL-S mixtures”

Table SMELL-R Combinations. This Table lists the composition of stimulifor all 16 levels of SMELL-R (v1) and SMELL-R (v2). In the triangletests, the ODD odor is presented in a single vial, and the CONTROL odoris presented in two identical vials. The task is for the subject tosniff the three vials and select the one vial containing the ODD odor.All mixtures have equal volumes of each component. SMELL-R (v1) - level1 - ODD odor SMELL-R (v1) - level 1 - CONTROL odor CID Odor nameDilution CAS # CID Odor name Dilution CAS # 7720 2-ethyl-1-hexanol  1/1,000 104-76-7 7969 benzenethiol  1/100,000 108-98-5 10364 carvacrol 1/1000 499-75-2 7731 4-methylanisole 1/1,000 104-93-8 3314 eugenol  1/1,000 97-53-0 13216 decahydro-2-naphthol 1/1,000 825-51-4 60542-phenylethanol  1/100 60-12-8 7770 propyl butyrate 1/1,000 105-66-814514 2-acetyl-5-methylfuran  1/1000 1193-79-9 8093 2-octanone 1/1,000111-13-7 261 butyraldehyde   1/1,000 123-72-8 7826 methyl heptanoate1/1,000 106-73-0 12327 ethyl undecanoate 1/10 627-90-7 7559 methylphenylacetate 1/1,000 101-41-7 62378 dihydrojasmone 1/10 1128-08-1101010 2-methyl-4-propyl-1,3-oxathi

 1/100,000 67715-80-4 7795 isoamyl butyrate 1/10 106-27-4 69432-isopropylphenol 1/1,000 88-69-7 24020 ethyl 2-methylbutyrate  1/10007452-79-1 22873 hexyl hexanoate 1/10   6378-65-0 61293ethyl-3-hydroxyhexanoate pure 2305-25-1 61151 methyl 2-methoxybenzoate1/100  606-45-1 6826 dimethyl anthranilate  1/100 85-91-6 7983 butylbutyrate 1/1,000 109-21-7 13187 2-nonanone  1/100 821-55-6 5195392-(1-methylpropyl)thiazole  1/10,000 18277-27-5 2969 decanoic acid 1/10334-48-5 61204 delta-undecalactone pure 710-04-3 7583 diphenyl ether  1/1,000 101-84-8 957 octanol 1/10   111-87-5 8129 heptanol  1/1000111-70-6 61177 hexyl formate 1/1,000 620-33-4 31225 phenethyl propionate 1/100 122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerolactone 1/100 108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10 111-14-8 12097 5-methylfurfural 1/1,000 620-02-0 1001phenethylamine   1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene  1/1000 110-02-1 8375 2-hydroxyacetophenone 1/1,000110-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-methyphenol 1/100,000 93-51-6 12741 2-decanone 1/10 693-54-9 8063 valeraldehyde 1/10,000 118-62-3 1068 methyl sulfide   1/1,000 75-18-3 11364-methyl-5-thiazoleethanol 1/1,000 137-00-8 7410 acetophenone   1/1,00098-86-2 8007 butylamine  1/10,000 109-73-9 16324 allyl butyrate  1/10002051-78-7 251531 phenethyl 2-furoate 1/100  7149-32-8 7335 carvylacetate  1/1000 97-42-7 1060 pyruvic acid  1/10,000 127-17-3 894406-acetyl-1,1,2,4,4,7-hexamethyltetralin 1/10 21145-77-7 60999 benzylphenylacetate 1/100  102-16-9 9024 α,α-dimethylphenethyl acetate 1/10151-05-3 11124 methyl propionate 1/1,000 554-12-1 660 dihydrocoumarin 1/100 119-84-6 454 octanal 1/1,000 124-13-0 7720 2-ethyl-1-hexanol  1/1,000 104-76-7 7969 benzenethiol  1/100,000 108-98-5 10364 carvacrol 1/1000 499-75-2 7731 4-methylanisole 1/1,000 104-93-8 3314 eugenol  1/1,000 97-53-0 13216 decahydro-2-naphthol 1/1,000 825-51-4 60542-phenylethanol  1/100 60-12-8 7770 propyl butyrate 1/1,000 105-66-814514 2-acetyl-5-methylfuran  1/1000 1193-79-9 8093 2-octanone 1/1,000111-13-7 261 butyraldehyde   1/1,000 123-72-8 7826 methyl heptanoate1/1,000 106-73-0 12327 ethyl undecanoate 1/10 627-90-7 7559 methylphenylacetate 1/1,000 101-41-7 62378 dihydrojasmone 1/10 1128-08-1101010 2-methyl-4-propyl-1,3-oxathi

 1/100,000 67715-80-4 7795 isoamyl butyrate 1/10 106-27-4 69432-isopropylphenol 1/1,000 88-69-7 24020 ethyl 2-methylbutyrate  1/10007452-79-1 22873 hexyl hexanoate 1/10   6378-65-0 61293ethyl-3-hydroxyhexanoate pure 2305-25-1 61151 methyl 2-methoxybenzoate1/100  606-45-1 6826 dimethyl anthranilate  1/100 85-91-6 7983 butylbutyrate 1/1,000 109-21-7 13187 2-nonanone  1/100 821-55-6 5195392-(1-methylpropyl)thiazole  1/10,000 18277-27-5 2969 decanoic acid 1/10334-48-5 61204 delta-undecalactone pure 710-04-3 7583 diphenyl ether  1/1,000 101-84-8 957 octanol 1/10   111-87-5 8129 heptanol  1/1000111-70-6 61177 hexyl formate 1/1,000 629-33-4 31225 phenethyl propionate 1/100 122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerolcatone 1/100 108-29-2 31266 allyl hexanote 1/1,000 123-68-2 8094 heptanoicacid 1/10 111-14-8 12097 5-methylfurfural 1/1,000 620-02-0 1001phenethylamine   1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene  1/1000 110-02-1 8375 2-hydroxyacetophenone 1/1,000118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-methylphenol 1/100,000 93-51-6 12741 2-decanone 1/10 693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1088 methyl sulfide   1/1,000 75-18-3 11364-methyl-5-thiazoleethanol 1/1,000 137-00-8 7410 acetophenone   1/1,00098-86-2 8007 butylamine  1/10,000 109-73-9 16324 allyl butyrate  1/10002051-78-7 251531 phenethyl 2-furoate 1/100  7149-32-8 7335 carvylacetate  1/1000 97-42-7 1060 pyruvic acid  1/10,000 127-17-3 894406-acetyl-1,1,2,4,4,7-hexamethyltetralin 1/10 21145-77-7 60999 benzylphenylacetate 1/100  102-16-9 9024 α,α-dimethlyphenethyl acetate 1/10151-05-3 11124 methyl propionate 1/1,000 554-12-1 660 dihydrocoumarin 1/100 119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 2 -ODD odor SMELL-R (v1) - level 2 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol    1/100,000108-98-5 7969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole  1/1,000 104-93-8 7731 4-methylanisole 1/1,000 104-93-8 3314 eugenol  1/1,000 97-53-0 13216 decahydro-2-na

1/1,000 825-51-4 6054 2-phenylethanol  1/100 60-12-8 7770 propylbutyrate 1/1,000 105-66-8 14514 2-acetyl-5-meth

 1/1000 1193-79-9 8093 2-octanone 1/1,000 111-13-7 261 butyraldehyde  1/1,000 123-72-8 7826 methyl heptano

1/1,000 106-73-0 12327 ethyl undecano

1/10 627-90-7 7559 methyl phenyla

1/1,000 101-41-7 62378 dihydrojasmon

1/10 1128-08-1 101010 2-methyl-4-pro

 1/100,000 67715-80-4 7795 isoamyl butyrat

1/10 106-27-4 6943 2-isopropylphe

1/1,000 88-69-7 24020 ethyl 2-methylb

 1/1000 7452-79-1 22873 hexyl hexanoat

1/10   6378-65-0 61293 ethyl-3-hydroxyl

pure 2305-25-1 61151 methyl 2-metho

1/100  606-45-1 6826 dimethyl anthra

 1/100 85-91-6 7983 butyl butyrate 1/1,000 109-21-7 13187 2-nonanone 1/100 821-55-6 519539 2-(1-methylpro

 1/10,000 18277-27-5 2969 decanoic acid 1/10 334-48-5 61204delta-undecala

pure 710-04-3 7583 diphenyl ether   1/1,000 101-84-8 957 octanol 1/10  111-87-5 8129 heptanol  1/1000 111-70-6 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl propi

 1/100 122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

 1/100 108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10 111-14-8 12097 5-methylfurfura

1/1,000 620-02-0 1001 phenethylamine   1/1,000 64-04-0 521238 3-octylacetate 1/10   4864-61-3 8030 thiophene  1/1000 110-02-1 83752-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10 693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide   1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone   1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate  1/1000 2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate  1/1000 97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10 21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10 151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

 1/100 119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 3 -ODD odor SMELL-R (v1) - level 3 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 14514 2-acetyl-5-meth

1/1000  1193-79-9 8093 2-octanone 1/1,000 111-13-7 261 butyraldehyde1/1,000 123-72-8 7826 methyl heptano

1/1,000 106-73-0 12327 ethyl undecano

1/10   627-90-7 7559 methyl phenyla

1/1,000 101-41-7 62378 dihydrojasmon

1/10   1128-08-1 101010 2-methyl-4-prop

 1/100,000 67715-80-4 7795 isoamyl butyrat

1/10   106-27-4 6943 2-isopropylphe

1/1,000 88-69-7 24020 ethyl 2-methylb

1/1000  7452-79-1 22873 hexyl hexanoat

1/10   6378-65-0 61293 ethyl-3-hydroxyl

pure 2305-25-1 61151 methyl 2-metho

1/100  606-45-1 6826 dimethyl anthra

1/100  85-91-6 7983 butyl butyrate 1/1,000 109-21-7 13187 2-nonanone1/100  821-55-6 519539 2-(1-methylprop

 1/10,000 18277-27-5 2969 decanoic acid 1/10   334-48-5 61204delta-undecala

pure 710-04-3 7583 diphenyl ether 1/1,000 101-84-8 957 octanol 1/10  111-87-5 8129 heptanol 1/1000  111-70-6 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl propi

1/100  122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

1/100  108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10   111-14-8 12097 5-methylfurfural 1/1,000 620-02-0 1001phenethylamine 1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene 1/1000  110-02-1 8375 2-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumar

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 4 -ODD odor SMELL-R (v1) - level 4 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptane 1/1,000 106-73-0 7826methyl heptano

1/1,000 106-73-0 12327 ethyl undecano

1/10   627-90-7 7559 methyl phenyla

1/1,000 101-41-7 62378 dihydrojasmon

1/10   1128-08-1 101010 2-methyl-4-prop

 1/100,000 67715-80-4 7795 isoamyl butyrat

1/10   106-27-4 6943 2-isopropylphe

1/1,000 88-69-7 24020 ethyl 2-methylb

1/1000  7452-79-1 22873 hexyl hexanoat

1/10   6378-65-0 61293 ethyl-8 hydroxyl

pure 2305-25-1 61151 methyl 2-metho

1/100  606-45-1 6826 dimethyl anthra

1/100  85-91-6 7983 butyl butyrate 1/1,000 109-21-7 13187 2-nonanone1/100  821-55-6 519539 2-(1-methylpro

 1/10,000 18277-27-5 2969 decanoic acid 1/10   334-48-5 61204delta-undecala

pure 710-04-3 7583 diphenyl ether 1/1,000 101-84-8 957 octanol 1/10  111-87-5 8129 heptanol 1/1000  111-70-6 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl propi

1/100  122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

1/100  108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10   111-14-8 12097 5-methylfurfural 1/1,000 620-02-0 1001phenethylamine 1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene 1/1000  110-02-1 8375 2-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 5 -ODD odor SMELL-R (v1) - level 5 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-prop

 1/100,000 67715-80-4 7795 isoamyl butyrat

1/10   106-27-4 6943 2-isopropylphe

1/1,000 88-69-7 24020 ethyl 2-methylb

1/1000  7452-79-1 22873 hexyl hexanoat

1/10   6378-65-0 61293 ethyl-3-hydroxy

pure 2305-25-1 61151 methyl 2-metho

1/100  606-45-1 6826 dimethyl anthra

1/100  85-91-6 7983 butyl butyrate 1/1,000 109-21-7 13187 2-nonanone1/100  821-55-6 519539 2-1-methylpro

 1/10,000 18277-27-5 2969 decanoic acid 1/10   334-48-5 61204delta-undecala

pure 710-04-3 7583 diphenyl ether 1/1,000 101-84-8 957 octanol 1/10  111-87-5 8129 heptanol 1/1000  111-70-6 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl prop

1/100  122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

1/100  108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10   111-14-8 12097 5-methylfurfural 1/1,000 620-02-0 1001phenethylamine 1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene 1/1000  110-02-1 8375 2-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 6 -ODD odor SMELL-R (v1) - level 6 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-prop

 1/100,000 67715-80-4 101010 2-methyl-4-prop

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61293 ethyl-3-hydroxyl

pure 2305-25-1 61151 methyl 2-metho

1/100  606-45-1 6826 dimethyl anthra

1/100  85-91-6 7983 butyl butyrate 1/1,000 109-21-7 13187 2-nonanone1/100  821-55-6 519539 2-(1-methylpro

 1/10,000 18277-27-5 2969 decanoic acid 1/10   334-48-5 61204delta-undecala

pure 710-04-3 7583 diphenyl ether 1/1,000 101-84-8 957 octanol 1/10  111-87-5 8129 heptanol 1/1000  111-70-6 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl propi

1/100  122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

1/100  108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10   111-14-8 12097 5-methytfurural 1/1,000 620-02-0 1001phenethylamine 1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene 1/1000  110-02-1 8375 2-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-6 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acety-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 7 -ODD odor SMELL-R (v1) - level 7 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 13187 2-nonanone 1/100  821-55-6 519539 2-(1-methylpro

 1/10,000 18277-27-5 2969 decanoic acid 1/10   334-48-5 61204delta-undecala

pure 710-04-3 7583 diphenyl ether 1/1,000 101-84-8 957 octanol 1/10  111-87-5 8129 heptanol 1/1000  111-70-6 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl prop

1/100  122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

1/100  108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10   111-14-8 12097 5-methylfurfural 1/1,000 620-02-0 1001phenethylamine 1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene 1/1000  110-02-1 8375 2-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-deoanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 8 -ODD odor SMELL-R (v1) - level 8 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-65-8 8093 2-octanone 1/1.000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 87715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 7583 diphenyl ether 1/1,000 101-84-8 957 octanol 1/10  111-87-5 8129 heptanol 1/1000  111-70-6 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl propl

1/100  122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

1/100  108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10   111-14-8 12097 5-methylfurfural 1/1,000 620-02-0 1001phenethylamine 1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-38030 thiophene 1/1000  110-02-1 8375 2-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 9 -ODD odor SMELL-R (v1) - level 9 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 31225 phenethyl prop

1/100  122-70-3 8174 decanol 1/10   112-30-1 7921 gamma-valerol

1/100  108-29-2 31266 allyl hexanoate 1/1,000 123-68-2 8094 heptanoicacid 1/10   111-14-8 12097 5-methylfurfura

1/1,000 620-02-0 1001 phenethytamine 1/1,000 64-04-0 521238 3-octylacetate 1/10   4864-61-3 8030 thiophene 1/1000  110-02-1 83752-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumar

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 10 -ODD odor SMELL-R (v1) - level 10 - CONTROL odor CID Odor name DilutionCAS # CD Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-988 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-187 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  60845-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 8174 decanol 1/10   112-30-1 8174 decanol 1/10   112-30-1 31266allyl hexanoate 1/1,000 123-68-2 31266 allyl hexanoate 1/1,000 123-68-28094 heptanoic acid 1/10   111-14-8 12097 5-methylfurfural 1/1,000620-02-0 1001 phenethylamine

1/1,000 64-04-0 521238 3-octyl acetate 1/10   4864-61-3 8030 thiophene1/1000  110-02-1 8375 2-hydroxyaceto

1/1,000 118-984 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 11 -ODD odor SMELL-R (v1) - level 11 - CONTROL odor CID Odor name DilutionCAS # CD Odor name Dilution CAS # 7969 benzenethiol  1/100,000 408-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-prop

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 8174 decanol 1/10   112-30-1 8174 decanol 1/10   112-30-1 31266allyl hexanoate 1/1,000 123-68-2 31266 allyl hexanoate 1/1,000 123-68-212097 5-methylfurfura

1/1,000 620-02-0 12097 5-methylfurfura

1/1,000 620-02-0 521238 3-octyl acetate 1/10   4864-61-3 521238 3-octylacetate 1/10   4864-61-3 8030 thiophene 1/1000  110-02-1 83752-hydroxyaceto

1/1,000 118-93-4 8914 nonanol pure 143-08-8 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyt-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 12 -ODD odor SMELL-R (v1) - level 12 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 30932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7963 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 8174 decanol 1/10   112-30-1 8174 decanol 1/10   112-30-1 31266allyl hexanoate 1/1,000 123-68-2 31266 allyl hexanoate 1/1,000 123-68-212097 5-methylfurfura

1/1,000 620-02-0 12097 5-methylfurfura

1/1,000 620-02-0 521238 3-octyl acetate 1/10   4864-61-3 521238 3-octylacetate 1/10   4864-61-3 8375 2-hydroxyaceto

1/1,000 118-93-4 8375 2-hydroxyaceto

1/1,000 118-93-4 7144 2-methoxy-4-m

 1/100,000 93-51-6 7144 2-methoxy-4-m

 1/100,000 93-51-6 12741 2-decanone 1/10   693-54-9 8063 valeraldehyde 1/10,000 110-62-3 1068 methyl sulfide 1/1,000 75-18-3 11364-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butylamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 13 -ODD odor SMELL-R (v1) - level 13 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 8174 decanol 1/10   112-30-1 8174 decanol 1/10   112-30-1 31266allyl hexanoate 1/1,000 123-68-2 31266 allyl hexanoate 1/1,000 123-68-212097 5-methylfurfura

1/1,000 620-02-0 12097 5-methylfurfura

1/1,000 620-02-0 521238 3-octyl acetate 1/10   4864-61-3 521238 3-octylacetate 1/10   4864-61-3 8375 2-hydroxyaceto

1/1,000 118-93-4 8375 2-hydroxyaceto

1/1,000 118-93-4 7144 2-methoxy-4-m

 1/100,000 93-51-6 7144 2-methoxy-4-m

 1/100,000 93-51-6 8063 valeraldehyde  1/10,000 110-62-3 8063valeraldehyde  1/10,000 110-62-3 1136 4-methyl-5-thia

1/1,000 137-00-8 1136 4-methyl-5-thia

1/1,000 137-00-8 7410 acetophenone 1/1,000 98-86-2 8007 butytamine 1/10,000 109-73-9 16324 allyl butyrate 1/1000  2051-78-7 251531phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60939 benzyl phenyla

1/100  102-169 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 14 -ODD odor SMELL-R (v1) - level 14 - CONTROL odor CIC Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropyiphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 8174 decano 1/10   112-30-1 8174 decanol 1/10   112-30-1 31266allyl hexanoate 1/1,000 123-68-2 31266 allyl hexanoate 1/1,000 123-68-212097 5-methylfurfura

1/1,000 620-02-0 12097 5-methylfurfura

1/1,000 620-02-0 521238 3-octyl acetate 1/10   4864-61-3 521238 3-octylacetate 1/10   4864-61-3 8375 2-hydroxyaceto

1/1,000 118-93-4 8375 2-hydroxyaceto

1/1,000 118-93-4 7144 2-methoxy-4-m

 1/100,000 93-51-6 7144 2-methoxy-4-m

 1/100,000 93-51-6 8062 valeraldehyde  1/10,000 110-62-3 8063valeraldehyde  1/10,000 110-62-3 1136 4-methyl-5-thia

1/1,000 137-00-8 1136 4-methyl-5-thia

1/1,000 137-00-8 8007 butylamine  1/10,000 109-73-9 8007 butylamine 1/10,000 109-73-9 251531 phenethyl 2-fur

1/100  7149-32-8 251531 phenethyl 2-fur

1/100  7149-32-8 7335 carvyl acetate 1/1000  97-42-7 1060 pyruvic acid 1/10,000 127-17-3 89440 6-acetyl-1,1,2,4

1/10   21145-77-7 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumar

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 15 -ODD odor SMELL-R (v1) - level 15 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,009 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isoprapylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 8174 decanol 1/10   112-30-1 8174 decanol 1/10   112-30-1 31266allyl hexanoate 1/1,000 123-68-2 31266 allyl hexanoate 1/1,000 123-68-212097 5-methylfurfural 1/1,000 620-02-0 12097 5-methylfurfural 1/1,000620-02-0 521238 3-octyl acetate 1/10   4864-61-3 521238 3-octyl acetate1/10   4864-61-3 8375 2-hydroxyaceto

1/1,000 118-93-4 8375 2-hydroxyaceto

1/1,000 118-93-4 7144 2-methoxy-4-m

 1/100,000 93-51-6 7144 2-methoxy-4-m

 1/100,000 93-51-6 8063 valeraldehyde  1/10,000 110-62-3 8063valeraldehyde  1/10,000 110-62-3 1136 4-methyl-5-thia

1/1,000 137-00-8 1136 4-methyl-5-thia

1/1,000 137-00-8 8007 butylamine  1/10,000 109-73-9 8007 butylamine 1/10,000 109-73-9 251531 phenethyl 2-fur

1/100  17149-32-8 251531 phenethyl 2-fur

1/100  7149-32-8 1060 pyruvic acid  1/10,000 127-17-3 1060 pyruvic acid 1/10,000 127-17-3 60999 benzyl phenyla

1/100  102-16-9 60999 benzyl phenyla

1/100  102-16-9 9024 α,α-dimethylph

1/10   151-05-3 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v1) - level 16 -ODD odor SMELL-R (v1) - level 16 - CONTROL odor CID Odor name DilutionCAS # CID Odor name Dilution CAS # 7969 benzenethiol  1/100,000 108-98-57969 benzenethiol  1/100,000 108-98-5 7731 4-methylanisole 1/1,000104-93-8 7731 4-methylanisole 1/1,000 104-93-8 13216 decahydro-2-na

1/1,000 825-51-4 13216 decahydro-2-na

1/1,000 825-51-4 7770 propyl butyrate 1/1,000 105-66-8 7770 propylbutyrate 1/1,000 105-66-8 8093 2-octanone 1/1,000 111-13-7 80932-octanone 1/1,000 111-13-7 7826 methyl heptano

1/1,000 106-73-0 7826 methyl heptano

1/1,000 106-73-0 7559 methyl phenyla

1/1,000 101-41-7 7559 methyl phenyla

1/1,000 101-41-7 101010 2-methyl-4-pro

 1/100,000 67715-80-4 101010 2-methyl-4-pro

 1/100,000 67715-80-4 6943 2-isopropylphe

1/1,000 88-69-7 6943 2-isopropylphe

1/1,000 88-69-7 22873 hexyl hexanoat

1/10   6378-65-0 22873 hexyl hexanoat

1/10   6378-65-0 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 7983 butyl butyrate 1/1,000 109-21-7 7983 butyl butyrate1/1,000 109-21-7 519539 2-(1-methylpro

 1/10,000 18277-27-5 519539 2-(1-methylpro

 1/10,000 18277-27-5 61204 delta-undecala

pure 710-04-3 61204 delta-undecala

pure 710-04-3 957 octanol 1/10   111-87-5 957 octanol 1/10   111-87-561177 hexyl formate 1/1,000 629-33-4 61177 hexyl formate 1/1,000629-33-4 8174 decanol 1/10   112-30-1 8174 decanol 1/10   112-30-1 31266allyl hexanoate 1/1,000 123-68-2 31266 allyl hexanoate 1/1,000 123-68-212097 5-methylfurfura

1/1,000 620-02-0 12097 5-methytfurfura

1/1,000 620-02-0 521238 3-octyl acetate 1/10   4864-61-3 521238 3-octylacetate 1/10   4864-81-3 8375 2-hydroxyaceto

1/1,000 118-93-4 8375 2-hydroxyaceto

1/1,000 118-93-4 7144 2-methoxy-4-m

 1/100,000 93-51-6 7144 2-methoxy-4-m

 1/100,000 93-51-6 8063 valeraldehyde  1/10,000 110-62-3 8063valeraldehyde  1/10,000 110-62-3 1136 4-methyl-5-thia

1/1,000 137-00-8 1136 4-methyl-5-thia

1/1,000 137-00-8 8007 butylamine  1/10,000 109-73-9 8007 butylamine 1/10,000 109-73-9 251531 phenethyl 2-fur

1/100  7149-32-8 251531 phenethyl 2-fur

1/100  7149-32-8 1060 pyruvic acid  1/10,000 127-17-3 1060 pyruvic acid 1/10,000 127-17-3 60999 benzyl phenyla

1/100  102-16-9 60999 benzyl phenyla

1/100  102-16-9 11124 methyl propion

1/1,000 554-12-1 11124 methyl propion

1/1,000 554-12-1 660 dihydrocoumari

1/100  119-84-6 454 octanal 1/1,000 124-13-0 SMELL-R (v2) - Level 1 -ODD odor SMELL-R (v2) - Level 1 - CONTROL odor CID Odor name DilutionCAS # CID Oder name Dilution CAS # 61005 2-phenoxyethyl isobutyrate pure103-60-6 8205 lauryl acetate 1/10   112-66-3 660 dihydrocoumarin 1/100 119-64-6 7770 propyl butyrate 1/1,000 105-66-8 14257 undecane pure1120-21-4 7797 ethyl heptanoate 1/100  106-30-9 62900 whiskey lactone1/1,000 39212-23-2 8049 diethyl sebacate pure 110-49-7 7820 dimethylsuccinate 1/10   106-65-0 14491 1,6-hexanedithiol  1/100,000 1191-43-161809 2-ethoxythiazole  1/10,000 15679-19-3 62144 2-furanmethanethiolformate    1/1,000,000 59020-90-5 454 octanal 1/1,000 124-13-0 8048ethyl decanoate 1/10   110-38-3 61027 butyl 10-undecenoate pure 109-42-28815 4-allylanisole 1/1,000 140-67-0 7749 ethyl propionate 1/1,000105-37-3 8878 allyl heptanoate 1/100  142-19-8 8797 p-tolyl acetate1/1,000 140-39-6 7361 furfuryl alcohol 1/1,000 98-00-0 7654 phenethylacetate 1/10   103-45-7 8635 methyl anthranilate 1/100  134-20-3 12327ethyl undecanoate 1/10   627-90-7 1001 phenethylamine 1/1,000 64-04-07793 (−)-citronellol 1/10   7540-51-4 62374 4-oxoisophorone 1/100 1125-21-9 61192 4-methyl-5-thiazoleethanol acetate 1/1,000 656-53-1 326cuminaldehyde 1/1,000 122-03-2 246728 3-octanone 1/1,000 106-68-3 615273-acetyl-2,5-dimethylfuran  1/10,000 10599-70-9 16255 Isoamyl octanoate1/10   2035-99-6 16324 allyl butyrate 1/1,000 2051-78-7 11364-methyl-5-thiazoteethanol 1/1,000 137-00-8 61151 methyl2-methoxyhenzoate 1/100  606-45-1 8118 propyl sulfide  1/100,000111-47-7 9609 diethyl sulfide  1/100,000 352-93-2 9589 3-acetylpyridine1/1,000 350-03-8 637568 geraniol 1/10   106-24-1 7632α,α-dimethylbenzenepropanal 1/10   103-05-9 7803 propyl propionate1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzylalcohol 1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylbutyrate 1/1000  7452-79-1 17898 2-methoxy-3-methylpyrazine 1/100,00 2847-30-5 14514 2-acetyl-5-methylfuran 1/1000  1193-79-9 7762ethyl butyrate 1/1,000 105-54-4 12348 pentyl acetate 1/1,000 628-63-78857 ethyl acetate 1/1,000 141-78-6 7792 3,7-dimethyl-1-octanol 1/1,000106-21-8 7799 ethyl octanoate pure 106-32-1 235414omega-pentadecalactone 1/10   106-02-5 1047212-acetyl-3,5(6)-dimethylpyrazine 1/1,000 54300-08-2 7761 diethylmalonate 1/100  105-53-3 11902 methyl 2-furoate 1/1,000 611-13-2 31244p-anisaldehyde 1/1,000 123-11-5 11529 butyl propionate 1/1,000 590-01-216537 terpinyl formate 1/1,000 2153-26-6 9862 6-methyl-5-hepten-2-one1/1,000 110-93-0 7826 methyl heptanoate 1/1,000 106-73-0 SMELL-R (v2) -Level 2 - ODD odor SMELL-R (v2) - Level 2 - CONTROL odor CID Odor nameDilution CAS # CID Odor name Dilution CAS # 8205 lauryl acetate 1/10  112-66-3 8205 lauryl acetate 1/10   112-66-3 7770 propyl butyrate1/1,000 105-66-8 7770 propyl butyrate 1/1,000 105-66-8 14257 undecanepure 1120-21-4 7797 ethyl heptanoat

1/100  106-30-9 62900 whiskey lactone 1/1,000 39212-23-2 8049 diethylsebacat

pure 110-40-7 7820 dimethyl succin

1/10   106-65-0 14491 1,6-hexanedithi

 1/100,000 1191-43-1 61809 2-ethoxythiazol

 1/10,000 15679-19-3 62144 2-furanmethan

   1/1,000,000 59020-90-5 454 octanal 1/1,000 124-13-0 8048 ethyldecanoate 1/10   110-38-3 61027 butyl 10-undec

pure 109-42-2 8815 4-allylanisole 1/1,000 140-67-0 7749 ethyl propionate1/1,000 105-37-3 8878 allyl heptanoate 1/100  142-19-8 8797 p-tolylacetate 1/1,000 140-39-6 7361 furfuryl alcohol 1/1,000 98-00-0 7654phenethyl aceta

1/10   103-45-7 8635 methyl anthrani

1/100  134-20-3 12327 ethyl undecano

1/10   627-90-7 1001 phenethylamine 1/1,000 64-04-0 7793 (−)-citronellol1/10   7540-51-4 62374 4-oxoisophoron

1/100  1125-21-9 61192 4-methyl-5-thia

1/1,000 656-53-1 326 cuminaldehyde 1/1,000 122-03-2 246728 3-octanone1/1,000 106-68-3 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16255 Isoamyl octano

1/10   2035-99-6 16324 allyl butyrate 1/1,000 2051-78-7 11364-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade

1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate

1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-6 98626-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 3 - ODD odor SMELL-R (v2) - Level3 - CONTROL odor CID Odor name Dilution CAS # CID Odor name Dilution CAS# 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 7820 dimethyl succin

1/10   106-65-0 14491 1,6-hexanedithi

 1/100,000 1191-43-1 61809 2-ethoxythiazol

 1/10,000 15679-19-3 62144 2-furanmethan

   1/1,000,000 59020-90-5 454 octanal 1/1,000 124-13-0 8048 ethyldecanoate 1/10   110-38-3 61027 butyl 10-undec

pure 109-42-2 8815 4-allylanisole 1/1,000 140-67-0 7749 ethyl propionate1/1,000 105-37-3 8878 allyl heptanoate 1/100  142-19-8 8797 p-tolylacetate 1/1,000 140-39-6 7361 furfuryl alcohol 1/1,000 98-00-0 7654phenethyl aceta

1/10   103-45-7 8635 methyl anthrani

1/100  134-20-3 12327 ethyl undecano

1/10   627-90-7 1001 phenethylamine 1/1,000 64-04-0 7793 (−)-citronellol1/10   7540-51-4 62374 4-oxoisophoron

1/100  1125-21-9 61192 4-methyl-5-thia

1/1,000 656-534 326 cuminaldehyde 1/1,000 122-03-2 246728 3-octanone1/1,000 106-68-3 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16255 Isoamyl octano

1/10   2035-99-6 16324 allyl butyrate 1/1,000 2051-78-7 11364-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyrioline 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 4 - ODD odor SMELL-R (v2) - Level4 - CONTROL odor CID Odor name Dilution CAS # CID Odor name Dilution CAS# 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-96-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 454 octanal 1/1,000 124-13-0 8048 ethyldecanoate 1/10   110-38-3 61027 butyl 10-undec

pure 109-42-2 8815 4-allylanisole 1/1,000 140-67-0 7749 ethyl propionate1/1,000 105-37-3 8878 allyl heptanoate 1/100  142-19-8 8797 p-tolylacetate 1/1,000 140-39-6 7361 furfuryl alcohol 1/1,000 98-00-0 7654phenethyl aceta

1/10   103-45-7 8635 methyl anthranil

1/100  134-20-3 12327 ethyl undecano

1/10   627-90-7 1001 phenethylamine 1/1,000 64-040 7793 (−)-citronellol1/10   7540-51-4 62374 4-oxoisophoron

1/100  1125-21-9 61192 4-methyl-5-thia

1/1,000 656-53-1 326 cuminaldehyde 1/1,000 122-03-2 246728 3-octanone1/1,000 106-68-3 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16255 Isoamyl octano

1/10   2035-99-6 16324 allyl butyrate 1/1,000 2051-78-7 11364-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzy

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethy-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade

1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 5 - ODD odor SMELL-R (v2) - Level5 - CONTROL odor CID Odor name Dilution CAS # CID Odor name Dilution CAS# 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 8048ethyl decanoate 1/10   110-38-3 8815 4-allylanisole 1/1,000 140-67-08815 4-allylanisole 1/1,000 140-67-0 7749 ethyl propionate 1/1,000105-37-3 8878 allyl heptanoate 1/100  142-19-8 8797 p-tolyl acetate1/1,000 140-39-6 7361 furfuryl alcohol 1/1,000 98-00-0 7654 phenethylaceta

1/10   103-45-7 8635 methyl anthrani

1/100  134-20-3 12327 ethyl undecano

1/10   627-90-7 1001 phenethylamine 1/1,000 64-04-0 7793 (−)-citronellol1/10   7540-51-4 62374 4-oxoisophoron

1/100  1125-21-9 61192 4-methyl-5-thia

1/1,000 656-53-1 326 cuminaldehyde 1/1,000 122-03-2 246728 3-octanone1/1,000 106-68-3 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16255 Isoamyl octano

1/10   2035-99-6 16324 allyl butyrate 1/1,000 2051-78-7 11364-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-met

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 6 - ODD odor SMELL-R (v2) - Level6 - CONTROL odor CID Odor name Dilution CAS # CID Odor name Dilution CAS# 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethane    1/1,000,000 59020-90-562144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 6048ethyl decanoate 1/10   110-38-3 8815 4-altylanisole 1/1,000 140-67-08815 4-allylanisole 1/1,000 140-67-0 8878 allyl heptanoate 1/100 142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361 furfuryl alcohol1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-0 7654 phenethylaceta

1/10   103-45-7 8635 methyl anthrani

1/100  134-20-3 12327 ethyl undecano

1/10   627-90-7 1001 phenethylamine 1/1,000 64-04-0 7793 (−)-citronellol1/10   7540-51-4 62374 4-oxoisophoron

1/100  1125-21-9 61192 4-methyl-5-thia

1/1,000 656-53-1 326 cuminaldehyde 1/1,000 122-03-2 246728 3-octanone1/1,000 106-68-3 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16255 Isoamyl octano

1/10   2035-99-6 16324 allyl butyrate 1/1,000 2051-78-7 11364-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-met

1/1000  1193-79-9 7762 ethvf butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 7 - ODD odor SMELL-R (v2) - Level7 - CONTROL odor CID Odor name Dilution CAS # CD Odor name Dilution CAS# 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 8048ethyl decanoate 1/10   10-38-3 8815 4-allylanisole 1/1,000 140-67-0 88154-allylanisole 1/1,000 140-67-0 8878 allyl heptanoate 1/100  142-19-88878 allyl heptanoate 1/100  142-19-8 7361 furfuryl alcohol 1/1,00098-00-0 7361 furfuryl alcohol 1/1,000 98-00-0 8635 methyl anthrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 7793 (−)-citronellol 1/10   7540-51-4 623744-oxoisophoron

1/100  1125-21-9 61192 4-methyl-5-thia

1/1,000 656-53-1 326 cuminaldehyde 1/1,000 122-03-2 246728 3-octanone1/1,000 106-68-3 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16255 Isoamyl octano

1/10   2035-99-6 16324 allyl butyrate 1/1,000 12051-78-7 11364-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 8 - ODD odor SMELL-R (v2) - Level8 - CONTROL odor CID Odor name Dilution CAS # CID Odor name Dilution CAS# 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoat

1/10   110-38-3 8048 ethyl decanoate 1/10   110-38- 3 88154-allylanisole 1/1,000 140-67-0 8815 4-allylanisole 1/1,000 140-67-08878 allyl heptanoate 1/100  142-19-8 8878 allyl heptanoate 1/100 142-19-8 7361 furfuryl alcohol 1/1,000 98-00-0 7361 furfuryl alcohol1/1,000 98-00-0 8635 methyl anthrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 246728 3-octanone 1/1,000 106-68-3 615273-acetyl-2,5-di

 1/10,000 10599-70-9 16255 Isoamyl octano

1/10   2035-99-6 16324 allyl butyrate 1/1,000 2051-78-7 11364-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetytoyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propional 1/1,000 106-36-5 8082 piperidine 1/10,000 110-89-4 7409 α-methylbenzy

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl maionat

1/100  105-53-3 11902 methyl 2-furoat

1/1.000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 9 - ODD odor SMELL-R (v2) - Level9 - CONTROL odor CID Odor name Dilution CAS # CID Odor name Dilution CAS# 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8043 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 8048ethyl decanoate 1/10   110-38-3 8815 4-allylanisole 1/1,000 140-57-08815 4-allylanisole 1/1,000 140-67-0 8878 allyl heptanoate 1/100 142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361 furfuryl alcohol1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-0 8635 methylanthrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 1136 4-methyl-5-thia

1/1,000 137-00-8 61151 methyl 2-metho

1/100  606-45-1 8118 propyl sulfide  1/100,000 111-47-7 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 10 - ODD odor SMELL-R (v2) - Level10 - CONTROL odor CID Odor name Dilution CAS # CID Odor name DilutionCAS # 8205 laury acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 8048ethyl decanoate 1/10   110-38-3 8815 4-allylanisole 1/1,000 140-67-08815 4-allylanisole 1/1,000 140-67-0 8878 allyl heptanoate 1/100 142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361 furfuryl alcohol1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-0 8635 methylanthani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 9609 diethyl sulfide  1/100,000 352-93-2 9609 diethylsulfide  1/100,000 352-93-2 9589 3-acetylpyridine 1/1,000 350-03-8637566 geraniol 1/10   106-24-1 7632 α,α-dimethylbe

1/10   103-05-9 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl

1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimmethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 11 - ODD odor SMELL-R (v2) - Level11 - CONTROL odor CID Odor name Dilution CAS # CID Odor name DilutionCAS # 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 8048ethyl decanoate 1/10   110-38-3 8815 4-allylanisole 1/1,000 140-67-08815 4-allylanisole 1/1,000 140-67-0 8878 allyl heptanoate 1/100 142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361 furfuryl alcohol1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-0 8635 methylanthrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamin

1/1,000 64-04-0 1001 phenethylamine 1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 9609 diethyl sulfide  1/100,000 352-93-2 9609 diethylsulfide  1/100,000 352-93-2 637566 geraniol 1/10   106-24-1 637566geraniol 1/10   106-24-1 7803 propyl proplona

1/1,000 106-36-5 7803 propyl propiona

1/1,000 106-36-5 8082 piperidine  1/10,000 110-89-4 7409 α-methylbenzyl1/100  98-85-1 31265 ethyl hexanoate 1/100  123-66-0 24020 ethyl2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 12 - ODD odor SMELL-R (v2) - Level12 - CONTROL odor CID Odor name Dilution CAS # CID Odor name DilutionCAS # 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoat

1/10   110-38-3 8048 ethyl decanoate 1/10   110-38-3 8815 4-allylanisole1/1,000 140-67-0 8815 4-allylanisole 1/1,000 140-67-0 8878 allylheptanoate 1/100  142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361furfuryl alcohol 1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-08635 methyl antbrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 9609 diethyl sulfide  1/100,000 352-93-2 9609 diethylsulfide  1/100,000 352-93-2 637566 geraniol 1/10   106-24-1 637566geraniol 1/10   106-24-1 7803 propyl propiona

1/1,000 106-36-5 7803 propyl propiona

1/1,000 106-36-5 7409 α-methylbenzyl 1/100  98-85-1 7409 α-methylbenzyl

1/100  98-85-1 24020 ethyl 2-methylb

1/1000  7452-79-1 24020 ethyl 2-methylb

1/1000  7452-79-1 17898 2-methoxy-3-m

 1/100,000 2847-30-5 14514 2-acetyl-5-meth

1/1000  1193-79-9 7762 ethyl butyrate 1/1,000 105-54-4 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 13 - ODD odor SMELL-R (v2) - Level13 - CONTROL odor CID Odor name Dilution CAS # CID Odor name DilutionCAS # 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoat

1/10   110-38-3 8048 ethyl decanoate 1/10   110-38-3 8815 4-allylanisole1/1,000 140-67-0 8815 4-allylanisole 1/1,000 140-67-0 8878 allylheptanoate 1/100  142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361furfuryl alcohol 1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-08635 methyl anthrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoro

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 9609 diethyl sulfide  1/100,000 352-93-2 9609 diethylsulfide  1/100,000 352-93-2 637566 geraniol 1/10   106-24-1 637566geraniol 1/10   106-24-1 7803 propyl propiona

1/1,000 106-36-5 7803 propyl propiona

1/1,000 106-36-5 7409 α-methylbenzyl 1/100  98-85-1 7409 α-methylbenzyl1/100  98-85-1 24020 ethyl 2-methylb

1/1000  7452-79-1 24020 ethyl 2-methylb

1/1000  7452-79-1 14514 2-acetyl-5-meth

1/1000  1193-79-9 14514 2-acetyl-5-meth

1/1000  1193-79-9 12348 pentyl acetate 1/1,000 628-637 12348 pentylacetate 1/1,000 628-63-7 8857 ethyl acetate 1/1,000 141-78-6 77923,7-dimethyl-1-

1/1,000 106-21-8 7799 ethyl octanoate pure 106-32-1 235414 omega-pentade1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  103-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 14 - ODD odor SMELL-R (v2) - Level14 - CONTROL odor CID Odor name Dilution CAS # CID Odor name DilutionCAS # 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 8048ethyl decanoate 1/10   110-38-3 8815 4-allylanisole 1/1,000 140-67-08815 4-allylanisole 1/1,000 140-67-0 8878 allyl heptanoate 1/100 142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361 furfuryl alcohol1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-0 8635 methylanthrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 9609 diethyl sulfide  1/100,000 352-93-2 9609 diethylsulfide  1/100,000 352-93-2 637566 geraniol 1/10   106-24-1 637566geraniol 1/10   106-24-1 7803 propyl propiona

1/1,000 106-36-5 7803 propyl propiona

1/1,000 106-36-5 7409 α-methylbenzyl 1/100  98-85-1 7409 α-methylbenzyl1/100  98-85-1 24020 ethyl 2-methylb

1/1000  7452-79-1 24020 ethyl 2-methylb

1/1000  7452-79-1 14514 2-acetyl-5-meth

1/1000  1193-79-9 14514 2-acetyl-5-meth

1/1000  1193-79-9 12348 pentyl acetate 1/1,000 628-63-7 12348 pentylacetate 1/1,000 628-63-7 7792 3,7-dimethyl-1-

1/1,000 106-21-8 7792 3,7-dimethyl-1-

1/1,000 106-21-8 235414 omega-pentade 1/10   106-02-5 235414omega-pentade 1/10   106-02-5 104721 2-acetyl-3,5(6)-

1/1,000 54300-08-2 7761 diethyl malonat

1/100  105-53-3 11902 methyl 2-furoat

1/1,000 611-13-2 31244 p-anisaldehyde 1/1,000 123-11-5 11529 butylpropionate 1/1,000 590-01-2 16537 terpinyl formate 1/1,000 2153-26-69862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 15 - ODD odor SMELL-R (v2) - Level15 - CONTROL odor CID Odor name Dilution CAS # CID Odor name DilutionCAS # 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoate 1/10   110-38-3 8048ethyl decanoate 1/10   110-38-3 8815 4-allylanisole 1/1,000 140-67-08815 4-allylanisole 1/1,000 140-67-0 8878 allyl heptanoate 1/100 142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361 furfuryl alcohol1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-0 8635 methylanthrani

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamine 1/1,000 64-04-0 1001 phenethylamine1/1,000 64-04-0 62374 4-oxoisophoron

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 9609 diethyl sulfide  1/100,000 352-93-2 9609 diethylsulfide  1/100,000 352-93-2 637566 geraniol 1/10   106-24-1 637566geraniol 1/10   106-24-1 7803 propyl propiona

1/1,000 106-36-5 7803 propyl propiona

1/1,000 106-36-5 7409 α-methylbenzyl 1/100  98-85-1 7409 α-methylbenzyl1/100  98-85-1 24020 ethyl 2-methylb

1/1000  7452-79-1 24020 ethyl 2-methylb

1/1000  7452-79-1 14514 2-acetyl-5-meth

1/1000  1193-79-9 14514 2-acetyl-5-meth

1/1000  1193-79-9 12348 pentyl acetate 1/1,000 628-63-7 12348 pentylacetate 1/1,000 628-63-7 7792 3,7-dimethyl-1-

1/1,000 106-21-8 7792 3,7-dimethyl-1-

1/1,000 106-21-8 235414 omega-pentade 1/10   106-02-5 235414omega-pentade 1/10   106-02-5 7761 diethyl malonat

1/100  105-53-3 7761 diethyl malonat

1/100  105-53-3 31244 p-anisaldehyde 1/1,000 123-11-5 31244p-anisaldehyde 1/1,000 123-11-5 11529 butyl propionate 1/1,000 590-01-216537 terpinyl formate 1/1,000 2153-26-6 9862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0 SMELL-R (v2) - Level 16 - ODD odor SMELL-R (v2) - Level16 - CONTROL odor CID Odor name Dilution CAS # CID Odor name DilutionCAS # 8205 lauryl acetate 1/10   112-66-3 8205 lauryl acetate 1/10  112-66-3 7770 propyl butyrate 1/1,000 105-66-8 7770 propyl butyrate1/1,000 105-66-8 7797 ethyl heptanoat

1/100  106-30-9 7797 ethyl heptanoat

1/100  106-30-9 8049 diethyl sebacat

pure 110-40-7 8049 diethyl sebacat

pure 110-40-7 14491 1,6-hexanedithi

 1/100,000 1191-43-1 14491 1,6-hexanedithi

 1/100,000 1191-43-1 62144 2-furanmethan

   1/1,000,000 59020-90-5 62144 2-furanmethan

   1/1,000,000 59020-90-5 8048 ethyl decanoat

1/10   110-38-3 8048 ethyl decanoate 1/10   110-38-3 8815 4-allylanisole1/1,000 140-57-0 8815 4-allylanisole 1/1,000 140-67-0 8878 allylheptanoate 1/100  142-19-8 8878 allyl heptanoate 1/100  142-19-8 7361furfuryl alcohol 1/1,000 98-00-0 7361 furfuryl alcohol 1/1,000 98-00-08635 methyl anthran

1/100  134-20-3 8635 methyl anthrani

1/100  134-20-3 1001 phenethylamin

1/1,000 64-04-0 1001 phenethylamine 1/1,000 64-04-0 62374 4-oxoisophoro

1/100  1125-21-9 62374 4-oxoisophoron

1/100  1125-21-9 326 cuminaldehyde 1/1,000 122-03-2 326 cuminaldehyde1/1,000 122-03-2 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 61527 3-acetyl-2,5-di

 1/10,000 10599-70-9 16324 allyl butyrate 1/1,000 2051-78-7 16324 allylbutyrate 1/1,000 2051-78-7 61151 methyl 2-metho

1/100  606-45-1 61151 methyl 2-metho

1/100  606-45-1 9609 diethyl sulfide  1/100,000 352-93-2 9609 diethylsulfide  1/100,000 352-93-2 637566 geraniol 1/10   106-24-1 637566geraniol 1/10   106-24-1 7803 propyl propiona

1/1,000 106-36-5 7803 propyl propiona

1/1,000 106-36-5 7409 α-methylbenzyl 1/100  98-85-1 7409 α-methylbenzyl1/100  98-85-1 24020 ethyl 2-methylb

1/1000  7452-79-1 24020 ethyl 2-methylb

1/1000  7452-79-1 14514 2-acetyl-5-met

1/1000  1193-79-9 14514 2-acetyl-5-met

1/1000  1193-79-9 12348 pentyl acetate 1/1,000 628-63-7 12348 pentylacetate 1/1,000 628-63-7 7792 3,7-dimethyl-1-

1/1,000 106-21-8 7792 3,7-dimethyl-1-

1/1,000 106-21-8 235414 omega-pentad

1/10   106-02-5 235414 omega-pentade 1/10   106-02-5 7761 diethylmalonat

1/100  105-53-3 7761 diethyl malonat

1/100  105-53-3 31244 p-anisaldehyde 1/1,000 123-11-5 31244p-anisaldehyde 1/1,000 123-11-5 16537 terpinyl formate 1/1,000 2153-26-616537 terpinyl formate 1/1,000 2153-26-6 9862 6-methyl-5-hep

1/1,000 110-93-0 7826 methyl heptano

1/1,000 106-73-0

indicates data missing or illegible when filed

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This reference listing is not an indication that any of the referencesis material to patentability.

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Although the present disclosure has been described with respect to oneor more particular embodiments and/or examples, it will be understoodthat other embodiments and/or examples of the present disclosure may bemade without departing from the scope of the present disclosure.

1. A mixture comprising from 2-30 compounds selected from the groupconsisting of: butyraldehyde, cuminaldehyde, octanal, dihydrocoumarin,octanol, phenethylamine, pyruvic acid, methyl sulfide,4-methyl-5-thiazoleethanol, decanoic acid, eugenol,2-phenylethanol,dimethyl anthranilate, 2-isopropylphenol, 2-methoxy-4-methylphenol,carvyl acetate, furfuryl alcohol, α-methylbenzyl alcohol, acetophenone,methyl phenylacetate, diphenyl ether, α,α-dimethylbenzenepropanol,phenethyl acetate, 2-ethyl-1-hexanol, 4-methylanisole, ethyl propionate,diethyl malonate, ethyl butyrate, propyl butyrate,3,7-dimethyl-1-octanol, (−)-citronellol, isoamyl butyrate, ethylheptanoate, ethyl octanoate, propyl propionate, dimethyl succinate,methyl heptanoate, gamma-valerolactone, benzenethiol, butyl butyrate,butylamine, thiophene, ethyl decanoate, diethyl sebacate, valeraldehyde,piperidine, 2-octanone, heptanoic acid, propyl sulfide, heptanol,decanol, lauryl acetate, 2-hydroxyacetophenone, methyl anthranilate,p-tolyl acetate, 4-allylanisole, ethyl acetate, allyl heptanoate,nonanol, α,α-dimethylphenethyl acetate, 3-acetylpyridine diethylsulfide, 6-methyl-5-hepten-2-one, carvacrol, methyl propionate, butylpropionate, methyl 2-furoate, 5-methylfurfural, ethyl undecanoate,pentyl acetate, 2-decanone, 2-nonanone, decahydro-2-naphthol, undecane,1,6-hexanedithiol, 2-acetyl-5-methylfuran, Isoamyl octanoate, allylbutyrate, terpinyl formate, 2-methoxy-3-methylpyrazine, hexyl hexanoate,ethyl 2-methylbutyrate, phenethyl propionate, p-anisaldehyde, ethylhexanoate, allyl hexanoate, benzyl phenylacetate, 2-phenoxyethylisobutyrate, butyl 10-undecenoate, methyl 2-methoxybenzoate, hexylformate, 4-methyl-5-thiazoleethanol acetate, delta-undecalactone,ethyl-3-hydroxyhexanoate, 3-acetyl-2,5-dimethylfuran, 2-ethoxythiazole,2-furanmethanethiol formate, 4-oxoisophorone, dihydrojasmone, whiskeylactone, 6-acetyl-1,1,2,4,4,7-hexamethyltetralin,2-methyl-4-propyl-1,3-oxathiane, 2-acetyl-3,5(6)-dimethylpyrazine,omega-pentadecalactone, 3-octanone, phenethyl 2-furoate,2-(1-methylpropyl)thiazole, 3-octyl acetate, geraniol, and combinationsthereof.
 2. The mixture of claim 1, comprising: 2-acetyl-5-methylfuran2-decanone 2-ethyl-1-hexanol 2-nonanone 2-phenylethanol6-acetyl-1,1,2,4,4,7-hexamethyltetralin acetophenone ally! butyratebutyraldehyde carvacrol carvyl acetate decanoic acid dihydrocoumarindihydrojasmone dimethyl anthranilate diphenyl ether ethyl2-methylbutyrate ethyl undecanoate ethyl-3-hydroxyhexanoate eugenolgamma-valerolactone heptanoic acid heptanol isoamyl butyrate methylsulfide nonanol phenethyl propionate phenethylamine thiophene, andα,α-dimethylphenethyl acetate.
 3. The mixture of claim 1 comprising:2-(1-methylpropyl)thiazole 2-hydroxyacetophenone 2-isopropylphenol2-methoxy-4-methylphenol 2-methyl-4-propyl-1,3-oxathiane 2-octanone3-octyl acetate 4-methyl-5-thiazoleethanol 4-methylanisole5-methylfurfural allyl hexanoate benzenethiol benzyl phenylacetate butylbutyrate butylamine decahydro-2-naphthol decanol delta-undecalactonehexyl formate hexyl hexanoate methyl 2-methoxybenzoate methyl heptanoatemethyl phenylacetate methyl propionate octanal octanol phenethyl2-furoate propyl butyrate pyruvic acid, and valeraldehyde.
 4. Themixture of claim 1 comprising: (−)-citronellol2-acetyl-3,5(6)-dimethylpyrazine 2-ethoxythiazole2-methoxy-3-methylpyrazine 2-phenoxyethyl isobutyrate 3-acetylpyridine3-octanone 4-methyl-5-thiazoleethanol 4-methyl-5-thiazoleethanol acetate6-methyl-5-hepten-2-one butyl 10-undecenoate butyl propionatedihydrocoumarin dimethyl succinate ethyl acetate ethyl butyrate ethylhexanoate ethyl octanoate ethyl propionate ethyl undecanoate Isoamyloctanoate methyl 2-furoate octanal phenethyl acetate piperidine propylsulfide p-tolyl acetate undecane whiskey lactone, andα,α-dimethylbenzenepropanol.
 5. The mixture of claim 1 comprising:1,6-hexanedithiol 2-acetyl-5-methylfuran 2-furanmethanethiol formate3,7-dimethyl-1-octanol 3-acetyl-2,5-dimethylfuran 4-allylanisole4-oxoisophorone allyl butyrate allyl heptanoate cuminaldehyde diethylmalonate diethyl sebacate diethyl sulfide ethyl 2-methylbutyrate ethyldecanoate ethyl heptanoate furfuryl alcohol geraniol lauryl acetatemethyl 2-methoxybenzoate methyl anthranilate methyl heptanoateomega-pentadecalactone p-anisaldehyde pentyl acetate phenethylaminepropyl butyrate propyl propionate terpinyl formate, and α-methylbenzylalcohol.
 6. The mixture of claim 1 comprising: 2-acetyl-5-methylfuran2-decanone 2-ethyl-1-hexanol 2-nonanone 2-phenylethanol6-acetyl-1,1,2,4,4,7-hexamethyltetralin acetophenone allyl butyratebutyraldehyde carvacrol carvyl acetate decanoic acid dihydrocoumarindihydrojasmone dimethyl anthranilate diphenyl ether ethyl2-methylbutyrate ethyl undecanoate ethyl-3-hydroxyhexanoate eugenolgamma-valerolactone heptanoic acid heptanol isoamyl butyrate methylsulfide nonanol phenethyl propionate phenethylamine thiophene, andα,α-dimethylphenethyl acetate.
 7. The mixture of claim 1 comprising:1,6-hexanedithiol 2-acetyl-5-methylfuran 2-furanmethanethiol formate3,7-dimethyl-1-octanol 3-acetyl-2,5-dimethylfuran 4-allylanisole4-oxoisophorone allyl butyrate allyl heptanoate cuminaldehyde diethylmalonate diethyl sebacate diethyl sulfide ethyl 2-methylbutyrate ethyldecanoate ethyl heptanoate furfuryl alcohol geraniol lauryl acetatemethyl 2-methoxybenzoate methyl anthranilate methyl heptanoateomega-pentadecalactone p-anisaldehyde pentyl acetate phenethylaminepropyl butyrate propyl propionate terpinyl formate, and α-methylbenzylalcohol.
 8. A mixture comprising a combination of at least two compoundsof claim 1, wherein at least one compound in the mixture is present at adilution selected from: 1:8 1:16 1:32 1:64 1:128 1:256 1:512 1:10241:2048 1:4096 1:8192 1:16384 1:32768 1:65536 1:131072 1:262144.
 9. Amethod comprising allowing an individual to nasally inhale odorsproduced by a combination of compounds of claim 8, and determiningwhether or not the individual perceives an odor from the combination ofthe compounds.
 10. The method of claim 9, wherein the individualperceives the odor, the method further comprising allowing theindividual to compare perception of the odor to at least one control,wherein the control is devoid of one, some or all of the compounds. 11.The method of claim 10, wherein the individual perceives the odor, themethod further comprising subsequently allowing the individual tonasally inhale odors produced by a dilution of the combination ofcompounds, and determining whether or not the individual perceives anodor from the dilution of the combination of the compounds, andoptionally repeating said method with one or more serial dilutions ofthe combinations of the compounds until the individual does not perceivethe odor, and generating a threshold value for olfactory sensitivityfrom a change in perception.
 12. A method comprising allowing anindividual to nasally inhale odors produced by a first combination ofcompounds of claim 1, and comparing perception of an odor produced bythe first combination of the compounds to perception of an odor producedby a second combination of compounds.
 13. The method of claim 12,further comprising replacing one or more compounds from the firstcombination of compounds with one or more compounds from the secondcombination of the compounds, and allowing the individual to nasallyinhale odors from the first and second combinations of the compounds todetermine a difference in the first and second combinations of thecompounds.
 14. The method of claim 13, further comprising repeating saidreplacing one or more compounds from the first combination of compoundswith one or more compounds from the second combination of the compounds,and allowing the individual to nasally inhale odors from the first andsecond combinations of the compounds, until the individual does notperceive a difference between the first and second combination of thecompounds, and generating a threshold value for olfactory resolutionfrom a change in perception.
 15. A kit comprising a mixture of at leasttwo compounds of claim 1 and at least one container comprising a mixtureof the compounds.
 16. The kit of claim 15, wherein the mixture of the atleast two compounds comprises a mixture of 2-30 compounds.
 17. The kitof claim 15, wherein the mixture of the at least two compounds comprisesa mixture of at least 30 compounds.
 18. The kit of claim 15, wherein themixture of the at least two compounds comprises a mixture consisting of30 compounds.
 19. The kit of claim 1, further comprising printedinstructions instructing a user to perform a method to determineolfactory sensitivity, olfactory resolution, or a combination thereof.